Increasingly severe sleep-related breathing disorders in older men appear to be associated with a greater risk of abnormal heart rhythms (arrhythmias), according to a report in the June 22 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. In addition, different types of breathing problems appear more closely associated with different categories of arrhythmia. Sleep-disordered breathing is a common condition, according to background information in the article. It causes a number of physiologic events that could be stressful to the cardiovascular system, including inadequate blood oxygen levels at night and activation of the sympathetic nervous system (associated with the body's fight-or-flight response).
Narcolepsy - from the French narcolepsie, which was derived from the Greek narke meaning numbness and lepsis meaning attack or seizure - is a chronic sleep disorder where the brain is unable to regulate the body's sleep-wake cycles. People with narcolepsy may feel an overwhelming urge to sleep at various points in the day, and they will often fall asleep spontaneously for a few seconds to a few minutes. In extreme cases, narcoleptics (people with narcolepsy) will remain asleep for over an hour. A study warned that people with narcolepsy who smoke are at a higher risk of burning. The majority of patients with narcolepsy/cataplexy experience a number of symptoms of eating disorders, with an irresistible craving for food and binge eating as the most prominent features, a study found.
A study in the July 1 issue of the journal SLEEP identified a distinct ECG-derived spectrographic phenotype, designated as narrow-band elevated low frequency coupling (e-LFCNB), that is associated with prevalent hypertension, stroke, greater severity of sleep disordered breathing and sleep fragmentation in patients suffering from obstructive sleep apnea (OSA). Results indicate that the odds ratio for prevalent stroke was 1.65 [CI: 1.19-29] in those with versus without the presence of e-LFCNB. The biomarker was detected in 1, 233 participants (23.5 percent), with statistically significant differences between those with and without it. Patients with the biomarker tended to be older (average 64.
Earlier parental-mandated bedtimes could help protect teens from depression and suicidal thoughts by lengthening sleep duration, according to a research abstract presented at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies. The study by James Gangwisch, PhD, of Columbia University in New York, examined data from 15, 659 adolescents. A total of 1, 143 teens (7.3 percent) suffered from depression and 2, 038 (13 percent) had suicidal thoughts. Adolescents with parental-mandated bedtimes at midnight or later were 25 percent more likely to suffer from depression and 20 percent more likely to have suicidal ideation compared with adolescents who had parental-mandated bedtimes of 10 p.
Some people who take the fast-acting sleep-aid zolpidem (Ambien) have been observed walking, eating, talking on the phone and even driving while not fully awake. Many often don't remember doing any of these activities the next morning. Similarly, this drug has been shown to awaken the minimally conscious into a conscious state. A new study by Georgetown University Medical Center (GUMC) researchers may help explain why these "awakenings" occur. The study, published online in the Proceedings of the National Academy of Sciences Monday, suggests that while some powerful brain circuits are shut down with zolpidem, the powerful sedative activates other circuits when deprived of activity.
Cephalon Submits NUVIGIL Supplemental New Drug Application For The Treatment Of Excessive Sleepiness Associated With Jet Lag Disorder
Cephalon, Inc. (Nasdaq: CEPH) announced that it has submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) requesting approval of NUVIGIL(R) (armodafinil) Tablets [C-IV] for the indication of improved wakefulness in patients with excessive sleepiness associated with jet lag disorder resulting from eastbound travel. Jet lag disorder is an acute condition that occurs when a person's internal body clock becomes disrupted as a result of rapid travel across several time zones. Based on U.S. Bureau of Labor Statistics findings, an estimated 70 million American travelers experience jet lag annually. Currently, there are no FDA-approved medications to improve wakefulness in travelers who experience the excessive sleepiness commonly associated with long flights.