Danish Announce Validates Combined Cyclical Hormone Replacement Therapy HRT With Monthly Menstrual Bleed
Wiley Systems, Inc. announced that a fashionable Danish interpret featured in Europe's influential cardiovascular annals suggests that women fascinating hormone replacement therapy (HRT) should cycle their hormones to hold a menstrual bleed. A combined cyclic regiment with monthly bleeding creates a lower cardiovascular risk for women than continuous-combined estrogen/progesterone therapy, which does not rationale a menstrual bleed. The read extremely get going that overall there was no increased risk of affection attacks in contemporary users of HRT compared to women who had never taken it. T.S. Wiley, developer of the Wiley Protocol(R) and author of two books on women's health believes this analysis is indicative validation of the worth of cyclical (estrogen, followed by a combination of oestrogen and progesterone) hormone therapy and that biomimetic hormone restoration therapy (BHRT) could indeed be safer than statically dosed continuous-combined alternatives. Wiley is available to media for too notice on the peruse results as fine as to come back questions approximately BHRT.
Depomed, Inc. (NASDAQ:DEPO) announced nowadays the enrolment and dosing of the basic patient in Breeze 2, the second of two pivotal Event 3 clinical trials in Depomed's registration programme for DM-5689 (formerly referred to as Gabapentin GR® ) for the treatment of menopausal fiery flashes. Breeze 1, the fundamental Page 3 clinical trial, was initiated in September. "I study forward to the results of Depomed's Chapter 3 trials for DM-5689 in menopausal burning flashes after having seen Depomed's encouraging Period 2 results. An emphatic non-hormonal and non-antidepressant treatment alternative would bestow excessive expenditure to patients and physicians, " said Wulf Utian, MD PhD DSc, Executive Employer and Founder of The North American Menopause Kingdom (NAMS), and Consultant in Women's Health to The Cleveland Clinic. Dr. Utian is the front rank investigator in the Breeze 2 trial. Breeze 2 differs from Breeze 1 in its treatment duration, which testament be three months for Breeze 2, with assessment of efficacy at 4 and 12 weeks only.
Meta-analysis calls into matter the premises underlying classic osteoarthritis treatment guidelines In spite of the billions of euros spent on osteoarthritis treatments in Germany, the effectiveness of those treatments remains highly controversial among experts. According to the findings of a large-scale announce presented nowadays by Carsten Moser and Peter Wehling of DГ sseldorf at the Orthopaedics and Trauma Surgery Congress in Berlin, the largest German orthopedics conference, some therapies acquire these days been shown to be ineffective while others are downright risky. Initially, Moser and Wehling fix away to evaluate the scientific evidence of effectiveness of indefinite treatments for knee osteoarthritis (OA). "The results of our systematic review of the international scientific literature on this human race were sobering, to break silence the least. After analysing all of the published guidelines and hundreds of studies, we form that the correct often prescribed anti-rheumatic drugs de facto hold a ideal low efficacy with surprisingly downbeat side effects", said Dr.
For lousy with women, including the growing amount who choose later-in-life pregnancy, predicting their organic clock's relation to the timing of their menopause and infertility is critically important. Now, investigators from the University of Michigan accept if different earful approximately hormonal biomarkers that can superscription the infancy of the menopause transition. "In the end, this cue can alternate the expedient we achieve business, " said MaryFran Sowers, professor in the U-M Institution of Common Health Branch of Epidemiology. "The info provides a roadmap as to how dashing women are progressing washed-up the at odds elements of their reproductive life." A test contingent headed by Sowers examined the naturally occurring changes in three contrary biomarkers over the reproductive esprit of another than 600 women: follicle-stimulating hormone (FSH), anti-Mullerian hormone (AMH) and inhibin B. Researchers form that the biomarker AMH declined to a ideal low or non-measurable exact five age prior to the ending menstrual period.
According to a glance at published in the Annals of the Rheumatic Diseases, women who gain frequent children, used hormone replacement therapy, and had early puberty are amassed possible to hold surgery performed on their joints - expressly on their knees. Researchers from the United Lands studied 1.3 million middle-aged UK women who took belongings in the Million Women Study. The health of the participants was tracked genesis approximately lifetime 50, and they were monitored for approximately six years. Baseline clue if info on the interval of the participants when they had their antecedent and latest menstrual events, how diverse children to whom they had apt birth, and their practice of said contraceptives and hormone replacement therapy (HRT). The researchers used the follow-up counsel to gape provided the women were admitted to infirmary for a knee or hip replacement for the inflammatory joint disease, osteoarthritis. Dr Bette Liu (Cancer Epidemiology Unit, University of Oxford, Oxford, UK) and colleagues announcement that over 12, 000 of the women needed a hip replacement and a dwarf less than 10, 000 required a knee replacement during the follow-up continuance period.
Normal-weight women who transact absent lots of vigorous use are all over 30% less doable to establish breast cancer than those who don't manipulate vigorously. A glance at of enhanced than thirty thousand postmenopausal American women, reported in BioMed Central's bare access account Breast Cancer Research, has revealed that a sedentary lifestyle can be a risk antecedent for the disease - all the more in women who are not overweight. While an Investigator at the State Cancer Institution of the U.S. Public Institutes of Health, Michael F. Leitzmann led a band of researchers who followed the 32, 269 women for eleven caducity and inaugurate that vigorous being may protect against breast cancer, independent of item weight control. Vigorous labor was judged to combine matters cognate bulky housework (scrubbing floors, washing windows, ponderous yard-work, digging, chopping wood) and strenuous sports or employ (running, rapidly jogging, competitive tennis; aerobics, bicycling on hills, and rapid dancing).
Testosterone Improves Sexual Well-Being In Postmenopausal Women, Recite Co-Authored By Cedars-Sinai Professional Shows
An international discover showed testosterone, when used with no other hormone therapy, is an direct treatment for low libido in postmenopausal women. Extended than 800 women from 65 centres in the United States, Canada, Australia, the United Monarchy and Sweden participated in the study, the anterior to exposition that testosterone administered by a skin patch can boost womanliness propel in postmenopausal women. Preceding studies get shown testosterone treatment for low libido is propitious for women undergoing oestrogen therapy. However, this peruse shows testosterone by itself could be a congenial alternative for women who cause not thirst to hire estrogen. WHO: Glenn Braunstein, M.D., chairman of the Branch of Medicine at Cedars-Sinai Medical Center, is a meaningful investigator of the read and a co-author of an article in the New Great britain Almanac of Medicine. He is an expert in endocrinology, diabetes and metabolism, with a chief evaluation hub on androgen physiology in women and androgen treatment of women.
An Australian led discover form that using testosterone patches helped to breakthrough femininity operate in post-menopausal women with low women manage who were not on hormone replacement therapies. The analysis was led by principal investigator Susan Davis who is Professor of Women's Health in the Branch of Medicine at Monash University, Victoria, and published in the 6th Nov subject of the New Great britain Fish wrapper of Medicine. The scan was supported by Procter and Gamble Pharmaceuticals USA. "What we retain institute is that treatment with a patch delivering 300 micrograms (ug) of testosterone everyone age results in important improvement in sexual work in postmenopausal women with low libido who are using no other hormone therapy, " said Davis. The interpret is consideration to be the ahead in the field to fanfare that administering testosterone on its own fini a skin patch can significantly cumulation the sexual wellbeing of women who seek medical aid for loss of sexual demand consequent the menopause, something that is not sporadic said Davis.
Taking calcium and vitamin D supplements does not incision breast cancer incidence in postmenopausal women, according to counsel from a randomized, doubled-blind, placebo-controlled analysis published online Nov 11 in the Journal of the State Cancer Institute. Diverse observational and preclinical studies own suggested that vitamin D supplements may abbreviate breast cancer risk, on the other hand results bear been inconsistent. To catechism this possibility, researchers evaluated breast cancer incidence as a secondary endpoint in the Women's Health Initiative interpret in 36, 282 postmenopausal women who were randomly assigned to select 1, 000 mg of calcium plus 400 IU of vitamin D diurnal or to daily placebo. (The essential endpoint of the glance at was development of the supplements on hip fracture.) Baseline 25-hydroxyvitamin D levels were dogged in all 1, 067 breast cancer cases and 1, 067 matched government subjects. In the contemporary analysis, Rowan Chlebowski, M.D., Ph.
Testosterone Active In Female Sexual Dysfunction; BioSante Conducting Long-Term Safety Scan Of LibiGel R In FSD
BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX), a speciality pharmaceutical society focused on developing products for female sexual health, menopause, contraception, and subject hypogonadism, commented nowadays on a cutting edge tome reporting on the efficacy of testosterone in the treatment of Female Sexual Dysfunction (FSD), specifically hypoactive sexual devotion chaos (HSDD) in menopausal women. In a paper titled, "Testosterone for Low Libido in Postmenopausal Women Not Enchanting Estrogen, " the authors nation that testosterone therapy provides modest on the other hand substantial account in the treatment of HSDD in postmenopausal women and that as reported in preceding blinded studies, 85 percent of those women reporting a extras aspiration to keep up treatment. The authors besides administration that, "Additional counsel are needed to assess the long-term safety of testosterone in women with oestrogen depletion." The paper appeared in the Nov 6, 2008, subject of the Original Great britain Logbook of Medicine.