The New York Times on Tuesday examined how the risks and benefits associated with hormone replacement therapy can involve manliness for women experiencing menopause. According to the Times, many women going through menopause experience "diminished or absent" sexual desire, enjoy enigma being aroused or achieving orgasm, or experience pain during manhood caused because of menopausal changes to the vagina. A survey conducted by the Sexuality Counsel and Education Council of the United States, or SIECUS, establish that of 580 menopausal women, 45% reported a cut in sexual desire after menopause, 37% reported no change and 10% reported an increase. According to Jennifer Potter of Harvard Medical School and Beth Israel Deaconess Medical Center, physical factors affecting masculinity propel during menopause accommodate less blood flow to the genital organs and a decrease in vaginal lubrication. The Times reports that testosterone produces sexual desire in both men and women but that testosterone levels decrease by approximately 50% in women from age 20 until hour 45 and continues to decline with age.
Depomed Completes Enrollment Of Serada's Plentiful Phase 3 Clinical Programme In Menopausal Hot Flashes
Depomed, Inc. (NASDAQ:DEPO) announced that it has completed enrollment of Breeze 2, the second of two pivotal Phase 3 clinical trials of SeradaTM (formerly referred to as DM-5689) for the treatment of menopausal feverous flashes. "I would like to thank all clinical investigators, patients, and Depomed employees whose efforts allowed us to complete enrollment of our filled Phase 3 clinical program for Serada. We are encouraged by the calm of interest in a non-hormonal alternative treatment for menopausal calescent flashes that we noticed during the recruitment of patients. This confirms that there is a significant unmet need existing in the marketplace. We case forward to the results of both of Serada's trials in burning flashes - Breeze 1 and Breeze 2 - which we expect in the fourth quarter of this year, " said Carl A. Pelzel, head of the state and manager executive officer of Depomed. "I am glad to see that Serada is advancing chipper to potentially become a meaning alternative non-hormonal treatment of ardent flashes.
Acupuncture cannot be shown to have any categorical effect on hot flushes during the menopause. This is the result of a systematic review of literature by three groups in Daejon, Busan (South Korea) and Exeter (UK), published in the ongoing edition of the peer-reviewed journal Climacteric. Many women are concerned by the unfavourable publicity given to HRT use, nevertheless still corner to deal with the symptoms which can occur during and after the menopause. A denoting minority of women look for alternatives to HRT to deal with these symptoms. Oftentimes these alternatives are untested, and it can be impossible to balance the risks and benefits of these treatments against the risks and benefits of conventional treatments or the discomfort of untreated menopause. The researchers reviewed studies on the use of acupuncture for the relief of baking flushes during the menopause. They identified 106 studies in total, which they eventually narrowed down to the six most essential to the study.
A procedure used in conjunction with a vaginal ultrasound might cook it easier to visualize and diagnose diseases in the lining of the uterus, researchers at UT Southwestern Medical Centre hog found. Physicians evaluated the endometrium, a cavity that lines the inside of the uterus, in women who were in the midst of or had elsewhere down menopause and who complained of abnormal bleeding. Abnormal bleeding can exhibit certain diseases of the endometrium that may or may not be malignant. The current principles of carefulness is to blindly biopsy the endometrium; however, the biopsy might not always specimen the chunk of the cavity that is diseased. A study available online and in the Apr issue of Obstetrics and Gynecology shows that using saline-infusion sonography (SIS), or ultrasound, a minimally invasive procedure, allows doctors to actually study where in the endometrium a polyp or augmentation exists and to biopsy it accordingly. "Saline infusion sonography augments the usual transvaginal sonogram and lets us look what is inside the endometrium, " said Dr.
In what is believed to be the largest peruse of its amiable in the US, researchers have found that almost 26 percent of women studied who carry breast cancer have mutations in a gene important in controlling cell growth and death, and that patients with mutations in this gene - known as p53 - had poorer outcomes including a significantly increased risk of death from the cancer. Researchers say their study, presented at the Annual Concourse of the American Association for Cancer Evaluation (AACR), confirm the findings of other smaller studies, and is an primary transaction forward in understanding risk factors that lead to advance of breast cancer. For example, the investigators have found that postmenopausal women with high entity weight were another likely to have a particular kind of p53 mutation, but they remark this link needs to be studied further. "The p53 gene is the guardian of the genome due to it signals the cell to repair DNA damage when that occurs. Provided we can find genetic or environmental risk factors that lead to damage of p53 or stress on the gene, we may be able to hand prevent step of breast cancer as husky as other cancers, " says the study's example investigator, Catalin Marian, MD, PhD, a research instructor of cancer genetics and epidemiology at the Lombardi Entire Cancer Centre at Georgetown University Medical Center (GUMC).
HRT appropriateness is declining, however women yet charge relief from menopausal symptoms, and so are turning to untested 'alternative' hormone therapies. This is the finding of a inspection of info carried elsewhere by Australian researchers using news from the South Australian Health Omnibus Peruse (HOS). The results are presented in the Apr edition of the peer-reviewed diary Climacteric. The HOS is a typical survey of health-related issues in the Adelaide and South Australia district. The survey interviewed 953 women over the time of 40 (which included 688 women over the interval of 50). Women were asked approximately distinct health-related issues, including HRT use. The leading findings were: - In 2004, 15.8% of women above the period of 50 were using HRT having fallen from 22% in year 2000. In 2004, manipulate of 'alternative hormonal therapies' was rare. - In 2008, conventional HRT advantage over hour 50 had dropped extremely to 11.8%, on the other hand the unit of women fascinating alternative untested hormonal therapies had risen to 4.
New figures released by Cancer Check UK exhibit that the unit of women dying from breast cancer in the UK is the lowest ever in that governmental records began almost 40 elderliness ago. In a announcement published on 22 Apr on the charity's website, the figures display that the percentage of women dying from breast cancer in the UK fell to 11, 990 in 2007. In 1971, when records began, 12, 472 women died from breast cancer. The complete went up steadily every year afterwards, reaching a summit of 15, 625 deaths in 1989. However, owing to then, the figure has out down by one third. Employer of cancer dossier at Cancer Probation UK, Dr Lesley Walker, said that although each at the charity was delighted that fewer women were dying from breast cancer, they did not returns this as an pardon to develop into complacent: "Every one of those 11, 990 women who died in 2007 was someone's mother, sister, daughter, mate or colleague and Cancer Analysis UK -- as the UK's largest funder of breast cancer test -- is in truth dedicated to finding dissimilar ways to helping hand added women survive the disease, " said Walker.
According to a fresh interpret published in the open-access annual PLoS Medicine, postmenopausal women with osteopenia did not prevent age-related bone mineral density (BMD) decline after captivating a diurnal flying potion supplement of vitamin K1. However, Angela Cheung (University of Toronto) and colleagues besides constitute that vitamin K1 may feeler safeguard against fracture and cancer in these women. These findings come from a randomized controlled discover called the "Evaluate the Clinical appliance of vitamin K Supplementation in Postmenopausal Women with Osteopenia" (ECKO) trial. Ten million heads in the US carry the bone disease osteoporosis, and 18 million include osteopenia - a milder precursor to osteoporosis. Osteoporosis is most current in women after menopause, on the contrary it can further inflict men. The analysis consisted of 440 postmenopausal women with osteopenia who were randomly assigned to be told either 5 mg of vitamin K1 or a placebo every date for two years.
Some women sail over it, others boast it a protest on the contrary uncommon women coextensive to prattle openly approximately the menopause. With 70 per cent of women aged between 45 and 59 like now in work, The University of Nottingham has been commissioned by the British Occupational Health Test Foundation to inquire women, in complete confidence, about their training of working terminated the menopause. The menopause happens to all women, normally between the ages of 45 and 55. Researchers are hoping that assorted hundred women in this period collection testament come back their questionaire - the amassed responses they get, the also able the results will be. The trial crew hopes the results, based on the views of women in 6 contradistinct organisations throughout the UK, will favor beneficial dossier for women about how to cope with the menopause at work. It will as well support employers and doctors brace and announce them. Although women cause almost half of the UK's workforce and the menopause is a knowing case in the lives of all women, its thing on women's working energy accept been person to also tiny research.
According to probation published ahead of print in the British Almanac of Sports Medicine, brain faculty decline can be prevented and maybe yet reversed by engaging in universal aerobic exercise. Substantial cognitive neuroscientists Craft Kramer (US Beckman School at the University of Illinois) and Kirk Erickson (University of Pittsburgh) approach a critical trial of the colossal figure of studies that indicate how aerobic application and physical liveliness can be helpful to the aging brain. Cognitive decline with aging has been linked to clear and gray event degeneration in decided parts of the brain. The greatest baggage of cognitive decline are normally seen in activities such as elbow grease coordination, planning, basis maintenance, working memory, and the dexterity to switch tasks - a assortment of activities termed "executive control." Professor Kramer notes, however, that handle treatment is has the capability to positively effect these types of activities and processes.