Paget's disease of bone, often just called Paget's disease or osteitis deformans, is a condition in which the normal cycle of bone growth is disrupted. The condition affects bone metabolism that allows for old bone to be recycled into new bone throughout life. This can cause bones to become weakened and deformed. In Paget's disease of bone, the rate at which old bone is broken down and new bone is formed is altered. Over time, it may result in bones becoming fragile. Common symptoms of Paget's disease include bone pain and deformity. The disease is named after Sir James Paget, the British surgeon who first described it in 1877. According to Medilexicon's medical dictionary : PagetВ s disease of bone is "a generalized skeletal disease, frequently familial, of older people in which bone resorption and formation are both increased, leading to thickening and softening of bones (the skull), and bending of weight-bearing bones." Paget's disease of bone is more common with age. After osteoporosis (brittle bones), Paget's disease is the second most common type of bone disease.
Life Spine R Announces FDA Clearance Of DYNA-LINK R Spinal System And PRESIDIO TM Spinal Plating System
Life Spine announced that the U.S. Food and Drug Administration (FDA) has given 510(k) marketing clearance to both the DYNA-LINK Spinal System and the PRESIDIO Spinal Plating System. The DYNA-LINK system features a next-generation stand-alone device that accommodates both fixed and variable angle screws. The PRESIDIO system is a thoracolumbar plating system that features multiple types of low-profile implants. Both offerings incorporate an innovative, zero-step locking mechanism and utilize comprehensive instrumentation designed to reduce surgical steps and intra-operative complexity. Michael S. Butler, Life Spine's president and CEO stated, "These two approvals are a testament to our commitment to rapidly achieving regulatory approval while at the same time introducing best-in-class products. Furthermore, these products will allow us to realize significant gains in the thoracolumbar fusion space." Life Spine is dedicated to improving the quality of life for spinal patients by increasing procedural efficiency and efficacy through innovative design, uncompromising quality standards, and the most technologically advanced manufacturing platforms.
St. George's Healthcare NHS Trust has ordered a SOMATOM® Definition Flash CT from Siemens Healthcare. The next generation system will be used as part of the hospital's major trauma and stroke centre to provide fast, low dose images in an emergency setting. Last year, St. George's Hospital was designated one of London's four major trauma centres by Healthcare for London. The hospital offers immediate access to specialist care and treatment for patients with serious injuries in the South West London and Surrey regions. The Definition Flash will support this service, enabling rapid whole-body scanning. The system carries out the fastest available scanning speed in CT (430 mm/s) with a temporal resolution of 75ms and can image a person with a height of six feet six inches in less than five seconds. The need to sedate paediatric patients is also reduced as they do not have to remain still for as long. Located close to the resuscitation area in Accident & Emergency, the Definition Flash will also perform acute stroke, vascular imaging and all emergency cases including paediatrics.
An international team of researchers suggests that running barefoot may be better for the feet and joints of the lower limbs because they found people who run barefoot or in minimal shoes strike their foot on the ground in such a way that they have almost no impact collision due to "heel-strike", unlike people who run in modern running shoes where the impact of the more prevalent heel-strike can be the equivalent of landing with two to three times of one's body weight. Dr Daniel E. Lieberman, a professor in Harvard University's new department of human evolutionary biology in Cambridge, Massachusetts, US, and colleagues, have written a paper about their findings the 28 January online issue of Nature. Lieberman and colleagues found that barefoot endurance runners tended to land on the forefoot (the ball of the foot) before bringing down their heel, or they landed on the middle part of the foot, and very rarely landed on the heel. But runners who wore running shoes tended to land on the rear foot, "facilitated by the elevated and cushioned heel of the modern running shoe".
An award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) will aid a partnership between the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center in finding new ways to use adult stem cells to speed repair of musculoskeletal soft tissue injuries. The five-year grant is for $3.75 million and involves collaboration between UC's Department of Biomedical Engineering and the Division of Developmental Biology at Cincinnati Children's. David Butler, PhD, UC professor of biomedical engineering, says the award is designated as a Bioengineering Research Partnership (BRP) to support a multidisciplinary research team applying an integrative approach to solving a major biomedical problem. For more than a decade, Butler's lab has focused on developing better repairs for the patellar tendon, the site where surgeons harvest tissue when reconstructing a torn anterior cruciate ligament (ACL). Because surgeons remove about a third of the tendon for the ACL, the site remains a problem for many patients.
For each action, there is an equal and opposite reaction. So after the surge in U.S. troops heading to Afghanistan, there will be an influx of injured veterans returning back home. But the U.S. Department of Defense has recruited its own "soldiers" in the battle against war casualties: a consortium of researchers who are improving care to wounded soldiers as well as the general public. Some of the orthopaedic researchers involved will lead a workshop about the program at the 56th annual meeting of the Orthopaedic Research Society (ORS), March 6 - 9, 2010, in New Orleans. They will also present an overview of the program during Extremity War Injuries V, a symposium that takes place Jan. 27 - 29 in Washington, D.C. Three members of the research consortium will address the ORS meeting with a workshop, "The Armed Forces Institute of Regenerative Medicine: Its Structure, Operations, and Goals, " on March 9. They will explain how the consortium called AFIRM for short is improving reconstructive and trauma care to the war wounded.
Since the beginning of Operations Iraqi Freedom and Enduring Freedom, there have been nearly 36, 000 battle- injured warriors, of which approximately 82 percent suffer extremity trauma. Many of these injuries are complicated by the effects of improvised explosive devices which cause injury patterns distinct from civilian trauma. Traditional wound-management guidelines simply fall short. In an effort to address the increasing number and severity of extremity war injuries among the nation's warriors serving in Iraq and Afghanistan, the American Academy of Orthopaedic Surgeons (AAOS), the Society of Military Orthopaedic Surgeons (SOMOS), the Orthopaedic Trauma Association (OTA), and the Orthopaedic Research Society (ORS) will bring together the nation's top civilian and military orthopaedic trauma surgeons and researchers for a two-day symposium January 27 - 29 to discuss barriers of return of function and duty and develop treatment principles. "Over the past several years, peer-reviewed orthopaedic research has been an essential element of our continued efforts to encourage researchers to focus on improving the treatment of high-energy extremity war injuries, " said Michael Bosse, MD, CAPT, USNR (Ret.
A team from Sinai Hospital's Rubin Institute for Advanced Orthopedics recently arrived in the Dominican Republic to treat Haitians injured in the earthquake. Team members include Shawn Standard, M.D., a pediatric orthopedic surgeon, Marie Gdalevitch, M.D., an orthopedic fellow and James Pepple, M.D., an anesthesiologist. This team is treating severely injured Haitians who have been transported out of field hospitals in Haiti to the more sophisticated CURE International Hospital in Santo Domingo, Dominican Republic. The Sinai team has already operated on a 22-year-old woman who has pelvic and foot fractures and is battling infection in her amputated fingers. "Bernadine is the lone survivor of a school that had 85 students, " said Standard. "After the building collapsed, she was able to crawl out through a window." The team will also operate on a Haitian orphan who underwent a leg amputation and now has an infection. Several doctors from the CURE International hospital have been in Port au Prince since the early days of the disaster, which has forced surgery to be delayed for Dominican children with dislocated hips and other complicated orthopedic problems.
Pfizer And Auxilium Announce Commencement Of European Regulatory Review Of XIAFLEXTM For The Treatment Of Dupuytren's Contracture
Pfizer Inc. (NYSE: PFE) and Auxilium Pharmaceuticals, Inc. (NASDAQ: AUXL) announced that Pfizer received notification from the European Medicines Agency that the Marketing Authorization Application (MAA) for XIAFLEX™ (collagenase clostridium histolyticum), a novel, first-in-class, biologic for the treatment of Dupuytren's contracture (a condition resulting in the contracture of the fingers into the palm), has completed the validation phase successfully. As a result, the scientific/technical review procedure commenced on 21 January 2010. "We are pleased to partner with Auxilium to bring forward what potentially could be the first approved pharmaceutical treatment option for patients suffering with Dupuytren's contracture, a condition which can significantly impact patients' ability to perform everyday tasks with their hands and therefore impacts quality of life, " said Michael Berelowitz, M.D., senior vice president, Clinical Development and Medical Affairs, Pfizer Specialty Care Business Unit.
Rickets is a disorder that affects children, causing poor development of the bones in the skeleton. It is usually caused by an extreme and prolonged vitamin D deficiency. The term rickets comes from the Old English word "wrickken", meaning to twist or bend. Rickets was common during Victorian times, but nowadays the condition is rare. Rickets in adults is known as osteomalacia or soft bones. According to Medilexicon's medical dictionary : Rickets is "A disease attributable to vitamin D deficiency, and characterized by overproduction and deficient calcification of osteoid tissue, with associated skeletal deformities, disturbances in growth, hypocalcemia, and sometimes tetany; usually accompanied by irritability, listlessness, and generalized muscular weakness; fractures are frequent." Rickets is among the most frequent childhood diseases in many developing countries. The predominant cause is a vitamin D deficiency. Lack of adequate calcium in the diet may also lead to rickets and cases of severe diarrhea and vomiting may be the cause of the deficiency.