Elsevier is pleased to announce that beginning with Volume 104 (2010) it will assume publication of the Annals of Allergy, Asthma & Immunology, the official journal of the American College of Allergy, Asthma & Immunology (ACAAI). The i>Annals of Allergy, Asthma & Immunology, published since 1942, will continue under the leadership of Editor Gailen D. Marshall, MD, PhD and a distinguished editorial board. The journal provides solid, peer-reviewed coverage of current clinical science (both research and practice-based) that is readily applicable to both the clinician and the researcher in the fields of allergy, asthma, and immunology. Each monthly issue also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency. Andrew Berin, Health Sciences Publisher, commented, "Elsevier is delighted to add i>Annals of Allergy, Asthma & Immunology to our publishing program. Working in partnership with the Editor, Editorial Board and the American College of Allergy, Asthma & Immunology, our goal is to continue to underscore the journal's mission of providing research and clinically relevant information to the widest possible audience of practicing allergists and immunologists.
As flu season got underway this fall, Dr. Catherine Monteleone, an allergist, noticed that her office started to receive an unusually high number of calls from people with egg allergy. They previously had avoided flu vaccines because of their sensitivity to eggs. This year, with all the attention being paid to the novel H1N1 influenza, those patients want to be protected against flu, and they contacted her to find out if they are candidates for inoculation. "Seasonal and H1N1 flu vaccines are produced in chicken embryos eggs so people who have egg allergy generally avoid them, " Monteleone, an associate professor of medicine at the UMDNJ-Robert Wood Johnson Medical School, explained. "But there are ways to get vaccinated." Patients first should consult with an allergist about the risks and benefits of vaccination, she recommends. Those with a known history of egg allergy or those who suspect an egg allergy must then undergo a skin test for egg allergy and for the vaccine. "Some people think they have an egg allergy because they experience abdominal upset from eating eggs, but that may not be a true allergy, " she said.
Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way. For more than a decade, a team led by Bruce S. Bochner, M.D., director of the Division of Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine, has studied a unique protein known as Siglec-8. This protein, whose name is an acronym for Sialic Acid-binding, Immunoglobulin-like LECtin number 8, is present on the surfaces of a few types of immune cells, including eosinophils, basophils and mast cells. These different cell types have diverse but cooperative roles in normal immune function and allergic diseases. When functioning correctly, they are a valuable aid to keeping the body healthy and infection-free. However, in allergic reactions and asthma attacks, the cells unleash an overwhelming response that typically harms the body more than it helps.
Circassia Announces Successful Results From Phase II Clinical Study Of ToleroMune R Cat Allergy Therapy
Circassia Ltd, a specialty biopharmaceutical company focused on allergy, announced positive results from a recently completed phase II clinical study of its ToleroMune(R) cat allergy therapy, which successfully identified the optimal dosing regimens to progress into late-stage development. The clinical trial, which was the first of its kind in the field of cat allergy immunotherapy, showed that Circassia's ToleroMune treatment was extremely well tolerated and greatly reduced sufferers' symptoms. Circassia conducted the double-blind study in Canada, where 121 subjects with confirmed cat allergies were randomised to receive placebo or one of four different treatment regimes with standardised doses of ToleroMune. The volunteers were exposed to cat allergens (aerosolised dander) in an environmental exposure chamber for 3 hours each day on four consecutive days, both before and after treatment. At set time points the subjects scored their ocular and nasal symptoms to allow investigators to measure the effect of the ToleroMune treatment.
Sublingual immunotherapy for the treatment of allergy symptoms caused by a wide variety of environmental inhalants has been effectively used in Europe. It should be employed to further treatment of allergies in the United States, where averse symptoms are largely undertreated, according to an invited article in the Apr 2009 issue of Otolaryngology-Head and Neck Surgery. A response to the article, published in the equivalent daybook issue, expresses cautious optimism, but calls for fresh research. Sublingual immunotherapy (SLIT) involves the administering of an allergen thought under the tongue, which in era reduces the patient's sensitivity to those allergens. The more prevalent alternative is subcutaneous immunotherapy, usually administered through an injection. The authors of the invited article note that despite allergic symptoms contributing heavily to poor affirmation of life, gigantic socioeconomic costs, and increased health issues, these syndromes remain underdiagnosed and undertreated.
If you're one of the millions who dread the spring allergy season, matters are looking up. A research glance at appearing in the May 2009 affair of the Journal of Leukocyte Biology shows how a side of American scientists hold identified a formerly unknown cellular switch that turns allergies and asthma both on and off. Equally important, this study too suggests that at least for some people with asthma and allergies, their problems might be caused by genes that prevent this switch from working properly. Taken together, this information is an conspicuous aboriginal step toward new medications that address the root causes of allergies, asthma and other consonant diseases. "This study uncovers some of the basic mechanisms that administration if or not general public have asthma and allergies and the severity of the symptoms, " said John Ryan, Ph.D., Professor of Biol at Virginia Commonwealth University, and a senior scientist involved in the research. "This understanding opens new avenues for treating these and other related diseases.
ImVisioN Therapeutics AG, a biopharmaceutical association pioneering intralymphatic immunotherapy (ILIT™ ), nowadays announced that it has obtained cold Episode I clinical results for its first place product, IVN201 (Cat-MAT), an immunotherapeutic product for the treatment of cat dander allergy. The study was conducted from August 2008 to Step 2009 in a complete of 20 patients with allergy to cat dander. The results demonstrated an excellent safety profile and exceptional tolerability in hypersensitive patients. In addition, the IVN201 program showed the cardinal signs of efficacy as measured by several clinical parameters. The double-blind, placebo-controlled clinical glance at was conducted at the University Hospital in Zurich, Switzerland. Based on these results, ImVisioN plans to close a Series B Financing Round by mid-2009, which will be used to fund Phase II clinical studies of Cat-MAT and to start clinical trials with Birch-MAT to treat birch pollen allergy and Mite-MAT to treat bullpen dust-mite allergy, respectively.
Avoiding foods may cause besides harm than good / Elimination diets can only assist children who have food sensitivity The number of children who have eczema has risen - one in five children are like now affected by this skin condition, which is often associated with an allergy. Researchers are not yet certain what is causing this growing problem. Many people deem that certain foods are responsible, or at least make the symptoms worse. However, in break condign published, the German Institute for Quality and Efficiency in Health Keeping (IQWiG) stresses that parents should be cautious about eliminating considerable foods like milk from their baby's or child's diet. Elimination diets probably individual help provided the babe has a proven food sensitivity or allergy. The Institute advises that most babies and small children with gentle eczema testament branch out absent of it, and parents will normally not have to convert their family's eating habits. Parents can direct up-to-date with the latest research on preventing allergies at the Institute's website, http://www.
Considerably exceeding family than formerly believed are allergic to the most common fragrance ingredient used in shampoos, conditioners and soap. A thesis presented at the Sahlgrenska Academy, University of Gothenburg, Sweden inaugurate that over 5% of those who underwent patch testing were allergic to the air oxidized conformation of the fragrance ingredient linalool. "I would suspect that about 2% of the comprehensive population of Sweden are sensitive to air oxidized linalool. That may not sound ideal much, on the contrary it is serious since linalool is so widely used as a perfume ingredient. Linalool is found in 60-80 percent of the perfumed hygiene products, washing up liquids and household cleaning agents that can be bought in the nearest supermarket, and it can be difficult for crowd who are allergic to avoid these products", says dermatologist Johanna BrГ red Christensson, author of the thesis. Encircling one workman in five in Sweden has some form of contact allergy.
Alcon (NYSE: ACL) and the Asthma and Allergy Foundation of America (AAFA) hold joined forces to spread the word approximately seasonal allergies and treatment over media outlets today. As the spring allergy season comes into full force, it is considerable for allergy sufferers to understand their treatment options. Seasonal allergies affect about 40 to 50 million people in the United States alone and are one of the top causes of absenteeism from work and school. "There are some dissimilar concepts and fashionable treatments for the springtime problems people are already experiencing, " said Bobby Lanier, M.D. and clinical professor at the University of North Texas Health Science Center. "Doctors enjoy just completed their annual conference on allergy and are keen to cement our friends at AAFA and communicate about these advances." In media interviews today, Dr. Lanier and other allergy experts testament affirm about the causes of seasonal allergies and what people can do in their everyday lives to support symptoms.