Patients who suffer from both allergic rhinitis and obstructive sleep apnea (OSA) may experience escalated symptoms of stress and fatigue. In a paper presented at the 2009 American Academy of Otolaryngology - Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO in San Diego, researchers studied 34 people who were diagnosed with obstructive sleep apnea. Among them, 12 people were classified in the allergic rhinitis group and 22 people in the control group. The researchers evaluated BMI (Body Mass Index), AHI (Apnea Hypopnea Index), RERA (Respiratory effort related arousals), LSAT (Lowest O2 Saturation), RQLQ (Rhinoconjunctivitis Quality of Life Questionnaire), ESS (Epworth sleepiness scale), stress score, fatigue score, and ability to cope, with questionnaires of both groups, then statistically compared mean scores of both groups. Allergic rhinitis is well known for increasing patients' daytime somnolence, fatigue, and decreasing cognitive performance, as does OSA.
A comparison of symptoms in patients with allergic rhinitis (AR) and non-allergic rhinitis (NAR) revealed that those with the NAR experienced worse symptoms. The findings are according to new research presented at the 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO, in San Diego, CA. The study assessed 78 patients with AR and 31 patients with non-allergic rhinitis (NAR), measuring quality of life (QOL) in both groups using a common questionnaire. To the surprise of the authors, NAR patients experienced a significantly higher symptom severity than their peers with AR, including having their regular and recreational activities affected, disrupted sleep, tiredness, and watery eyes. The study's authors believe that that many patients with allergy-type symptoms may have other, as-yet-undetermined causes of their symptoms, and that further research is warranted. Title: Quality of Life in Allergic and Non-Allergic Rhinitis Author: Nick Debnath, MD;
More than eighty children with personal stories of the challenges of managing food allergies spoke to their elected representatives and rallied for improved education and funding for food allergies during the third Food Allergy & Anaphylaxis Network's (FAAN) Kids' Congress on Capitol Hill last week. These Junior Ambassadors, speaking from their hearts, proudly represented the estimated 12 million Americans, including 3 million children, in the U.S. with food allergy, a potentially life-threatening condition. During the two-day event, children from all over the nation met with U.S. senators and representatives to urge funding for food allergy research and the passage of the Food Allergy and Anaphylaxis Management Act (FAAMA). FAAMA calls for voluntary national guidelines for food allergy management in schools and provides for incentive grants to implement these policies. The children also attended a Food Allergy Awareness Rally on Oct. 1 at 9 a.m. where they thanked food allergy leaders for their efforts.
Vaccination can lower children's risk of allergy. Cathleen Muche-Borowski and her coauthors present a clinical practice guideline for allergy prevention in the current issue of Deutsches Arzteblatt International (Dtsch Arztebl Int 2009; 106: 625-31). Allergic diseases are becoming increasingly common in Western industrialized countries. As there is still no etiologically based treatment of allergic asthma, hay fever, or atopic eczema, the prevention of these diseases is a matter of special importance. The majority of the 217 studies that the authors analyzed documented a protective effect of fish consumption in the diet of both the mother and the child. Soy-based baby food, in contrast, has no protective effect. In fact, because preparations of this type contain phytoestrogens, the authors even express concern about a potential harmful effect on health. Furthermore, delaying the introduction of solid food in the child's diet was not shown to have any beneficial effect on the development of allergy in the German cohort studies that the authors reviewed.
An apparent allergic reaction after an immunization should be investigated rather than avoiding future immunizations, which could leave patients at greater risk of disease, according to new medical guidelines published in the October issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI). There are approximately 235 million doses of vaccines administered in the United States each year, and only 1 dose per million causes anaphylaxis, a serious medical reaction. Fatalities from vaccine-induced anaphylaxis are exceedingly rare. "Local, injection site reactions and constitutional symptoms, especially fever, are common after vaccinations and do not contraindicate future doses, " said John M. Kelso, M.D., Division of Allergy, Asthma & Immunology at Scripps Clinic in San Diego, Calif., and a chief editor of the practice parameter. Dr. Kelso and colleagues recommend that all serious events occurring after vaccine administration should be reported to the Vaccine Adverse Event Reporting System (VAERS) at http://www.
The most comprehensive and detailed review of the burden posed by allergic disease in Scotland concludes that one in three of the Scottish population are affected by allergies at some point in their lives - higher than in England. The study, published in the October issue of the Journal of the Royal Society of Medicine, found that allergic disease costs NHS Scotland over В 130 million with the cost of GP consultations for asthma alone standing at В 786, 000. The study indicates that the lifetime prevalence for all allergic disease* is higher in Scotland than England, and in particular for eczema, asthma and allergic rhinitis. Allergic disorders accounted for more than 4% of GP consultations and 1.5% of hospital admissions. Professor Aziz Sheikh, Professor of Primary Care Research in the Centre for Population Health Sciences and Head of the Allergy & Respiratory Research Group at The University of Edinburgh, Scotland and one of the main authors of the study, commented: "Previous reports that looked at allergy disease in the UK have tended to overlook Scottish data.
A group led by Dr. Dieter BrГ mme at the University of British Columbia has demonstrated that glycosaminoglycans (GAGs) contribute to skeletal abnormalities in patients with lysosomal storage diseases. Their report can be found in the November 2009 issue of The American Journal of Pathology. Mucopolysaccharidoses (MPS) are a group of diseases in which the dysfunction of a lysosomal enzyme results in decreased breakdown of GAGs, a type of carbohydrate, in various tissues. These GAGs then collect in cells, causing severe cellular damage that affects bone, skeletal structure, connective tissue, and organs. In cells that break down bone, GAGs have been shown to inhibit the function of cathepsin K, an enzyme that breaks down collagen, which leads to insufficient space for new bone formation. As MPS patients have severe deficiencies in bone growth and development, Wilson et al hypothesized that cathepsin K inhibition may contribute to bone pathology in MPS patients. They found that both GAGs and cathepsin K were expressed in bone growth regions of a mouse model of MPS type I and that higher levels of cartilage accumulated in bone growth regions of MPS I mice than in their wild-type counterparts.
ISTA Pharmaceuticals Highlights Bepreve TM Clinical Data At The American College Of Clinical Pharmacy ACCP 2009 Annual Meeting
ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA) announced poster presentations of results from the Company's Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5% Phase 3 clinical studies in allergic conjunctivitis. The studies demonstrated Bepreve was safe and well-tolerated when given twice daily for six weeks in a healthy pediatric population as young as three years of age. The clinical findings were presented at the American College of Clinical Pharmacy (ACCP) 2009 Annual Meeting in Anaheim, CA, and were encore presentations from earlier meetings in 2009. In a poster previously presented at the American Academy of Allergy Asthma & Immunology 2009 Annual Meeting titled, "The Ocular Comfort and Safety of the Novel Anti-Histamine Bepotastine Besilate Ophthalmic Solution 1.5% in a Healthy Pediatric Population", ISTA presented results from a 6-week, multi-center, randomized, double-masked, placebo-controlled, parallel-group safety study. The study enrolled 861 individuals, of whom approximately 15% (127 subjects) were pediatric subjects.
The first genetic historical map of the Han Chinese, the largest ethnic population in the world, as they migrated from south to north over evolutionary time was published online by the American Journal of Human Genetics by scientists at the Genome Institute of Singapore (GIS). Based on genome-wide DNA variation information in over 6, 000 Han Chinese samples from 10 provinces in China, this new map provides information about the population structure and evolutionary history of this group of people that can help scientists to identify subtle differences in the genetic diversity of Asian populations. Understanding these differences may aid in the design and interpretation of studies to identify genes that confer susceptibility to such common diseases as diabetes in ethnic Chinese individuals. Understanding these differences also is crucial in exploring how genes and environment interact to cause diseases. With the genetic map, the GIS scientists were able to show that the northern inhabitants of China were genetically distinguishable from those in the south, a finding that seems very consistent with the Han Chinese's historical migration pattern.
Parents of children with food allergies are aware of the dangers lurking in Halloween treats, but little attention is paid to asthma, which can also be frightening for asthmatic children participating in Halloween festivities. "If your child suffers from asthma and/or allergies, be aware and prepared for potential triggers to ensure a safe and fun time for all during the holidays, " according to Clifford W. Bassett, MD, FAAAAI, Chair of the Public Education Committee of the American Academy of Allergy, Asthma & Immunology (AAAAI). The AAAAI offers these tips to help children with asthma and allergies safely enjoy the holiday and stay out of hospital emergency rooms: - Beware of costumes. Mold, dust and latex products can be major asthma triggers. Don't recycle costumes from the attic or basement, and wash new costumes before wearing. Halloween masks can trap dust and mold, so keep your child mask-free. - Don't enter homes. Keep your child on the door step of homes while trick-or-treating.