FDA Provides Clarity To Isis Regarding The Development Path For Mipomersen
Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) and Genzyme Corp. (Nasdaq: GENZ) announced that the FDA has provided guidance regarding approval requirements for mipomersen. The FDA has indicated that reduction of LDL-cholesterol is an acceptable surrogate endpoint for accelerated approval of mipomersen for use in patients with homozygous familial hypercholesterolemia (hoFH).
Analysis: Control Reduces Cardiovascular Risk By 42
Results of a new analysis of the Treating to New Targets (TNT) study show that intensive low-density lipoprotein (LDL) cholesterol-lowering in patients with stable coronary heart disease (CHD) whose systolic blood pressure was less than 140 mmHg reduced the risk of major cardiovascular events, including heart attack, stroke and resuscitated cardiac arrest, by 42 percent compared with less intensive LDL lowering and uncontrolled blood pressure of 140 mmHg or higher.
Higher Cholesterol Increases Risk Of Boichemical Failure After Radical Prostatectomy
Poor cholesterol management may not only affect a man's risk for prostate cancer, but also his risk of biomedical recurrence after prostatectomy, according to new data from Duke University.
5 Tips To Increase HDL Cholesterol
Thanks to powerful cholesterol-lowering statin drugs, driving down low-density lipoprotein (LDL), or "bad" cholesterol, has been the primary approach to improving cholesterol levels. But there's more to the story of cholesterol and cardiovascular risk than LDL alone.
Niacin's Role In Maintaining Good Cholesterol
A research team has uncovered the likely target of niacin (vitamin B3) in the liver, which should provide a clearer picture of how this vitamin helps maintain adequate HDL-cholesterol levels in the blood and thus lower the risk of heart disease.While niacin can increase plasma HDL levels, the mechanism of how it works has been mysterious, although it's believed that niacin does not actually increase HDL production.
CocoaVia Dark Chocolate Bars Shown To Lower Cholesterol
The results of a University of Illinois study have demonstrated an effective way to lower cholesterol levels - by eating chocolate bars."Eating two CocoaVia dark chocolate bars a day not only lowered cholesterol, it had the unexpected effect of also lowering systolic blood pressure, " said John Erdman, a U.
Gene Variation May Be Responsible For Lack Of Response By Some To Cholesterol-Lowering Drugs
A variation in the way the body processes a single protein may explain why some people don't respond well to drugs that lower "bad" cholesterol, according to a report in Circulation: Journal of the American Heart Association.The gene variation, called alternative splicing, explained 9 percent of the drugs' decreased power to reduce low-density lipoprotein (LDL) in study participants compared to people with the standard processing pathway.
Physicians And Patients Nationwide Discuss Controversial Results Of Recent Cholesterol Lowering Study
Sermo (http://www.sermo.com), the largest physician-only online community, today announced the results of a physician survey prompted by the swirl of media coverage following the release of ENHANCE trial data at the recent American College of Cardiology (ACC) conference.
Sorting Of CEA Modulated By Cholesterol, Implications For Inflammatory Bowel Disease
In polarized Caco-2 cells, cholesterol was depleted by a combination of synthesis inhibition and plasma membrane extraction with complexing agents. This led to an increased sorting of CEA to the basolateral surface. Interestingly, polarity was not significantly affected by this approach.
How Drug That Blocks Cholesterol Absorption From The Diet Works
A new study in the June issue of Cell Metabolism, a Cell Press publication, sheds light on the action of the drug ezetimibe (trade name Zetia), which is used to treat high cholesterol. Ezetimibe is unique among cholesterol-lowering drugs in that it works by cutting the amount of cholesterol taken in from the diet rather than by blocking cholesterol's manufacture in the body.