New Ways To Regulate Genes, Reduce Heart Damage Discovered By UC Researchers
Researchers at the University of Cincinnati (UC) are looking for ways to reduce or prevent heart damage by starting where the problem often begins: in the genes.Following a heart attack, cells die, causing lasting damage to the heart.Keith Jones, PhD, a researcher in the department of pharmacology and cell biophysics, and colleagues are trying to reduce post-heart attack damage by studying the way cells die in the heart - a process controlled by transcription factors.
New Source Of Heart Stem Cells Discovered
Researchers at Children's Hospital Boston are continuing to document the heart's earliest origins. Now, they have pinpointed a new, previously unrecognized group of stem cells that give rise to cardiomyocytes, or heart muscle cells. These stem cells, located in the surface of the heart, or epicardium, advance the hope of being able to regenerate injured heart tissue.
Neurologic Complications Of Heart Surgery Detailed In Comprehensive Review Article
Possible neurologic complications of heart surgery, ranging from headaches to strokes, are detailed in a new report in the online journal MedLink Neurology.The review article, which compiled results of previously published studies, was written by Dr.
Metabasis Announces Promising Results From Its Phase 1b Clinical Trial For MB07811, Its Novel Product Candidate For The Treatment Of Hyperlipidemia
Metabasis Therapeutics, Inc. (Nasdaq:MBRX) announced the results of its 14-day, Phase 1b multiple-dose clinical trial in subjects with mild hypercholesterolemia, which showed that MB07811 was safe and well tolerated across the seven doses tested, ranging from 0.
Lyme Disease Spriochetes Visualized In Vasculature
For the first time, scientists have directly observed the adherence andrelease of the bacterium Borrelia burgdorferi, which causes Lyme disease, according to a report released on June 19, 2008 in the open access journal PLoS Pathogens. B. burgdorferi is a bacterium of the spirocheteclass which causes Lyme disease.
Clinical Trial Of Nonsurgical Repair For Severe Mitral Valve Regurgitation Using Evalve MitraClip
The Cedars-Sinai Heart Institute is the lead enroller in the world for the Everest II Clinical Trial - a study comparing non-surgical repair for severe mitral valve regurgitation with conventional surgery. In 2005, a team of doctors at the Institute implanted the first Evalve MitraClip™
Nonsurgical Intervention For Aortic Valve Stenosis Clinical Trial
On Nov. 26, 2007, doctors at the Cedars-Sinai Heart Institute performed the first "transcatheter" minimally invasive replacement of an aortic heart valve in the western United States, using the SAPIEN transcatheter aortic heart valve developed by Edwards Lifesciences Corp.
Cedars-Sinai Heart Institute And The Watchman Left Atrial Appendage System
Doctors at the Cedars-Sinai Heart Institute were among the first in California to offer an experimental therapy for atrial fibrillation using the WATCHMAN Left Atrial Appendage System. This is a multicenter Phase II clinical trial, and Cedars-Sinai is one of about 60 centers nationwide participating in the study.
Gladstone And Izumi Bio In Partnership In Regenerative Medicine And Cardiovascular Disease
iZumi Bio, Inc. and The J. David Gladstone Institutes, an independent non-profit biomedical research organization, have announced a major research collaboration and licensing agreement to focus on applications for induced pluripotent stem (iPS) cells.
Gene Variants Linked To Metabolic Syndrome And HDL Cholesterol Levels
Nutrition researchers at Washington University School of Medicine in St. Louis have identified five common genetic variations that increase the risk of metabolic syndrome, a group of factors linked to heart disease and diabetes. Another variant they found appeared to protect against the condition.