KXO1 Can Inhibit The Growth Of Many Cancer Cell Types In Culture And The Growth Of Human Colon Cancer Cells In Animal Models
A novel compound, KXO1 (KX2-391), is a potential new cancer drug to prevent or treat recurrent and metastatic cancer, according to a study presented by Irwin H. Gelman, PhD, Department of Cancer Genetics, Roswell Park Cancer Institute (RPCI), at the 2008 annual meeting of the.
Getting Drugs To Tumors Quickly And With Less Toxicity Requires Novel Drug Delivery Methods
As promising cancer therapies and drugs emerge, researchers strive to find ways to deliver them to patients with minimal side effects. At the 2008 Annual Meeting of the American Association for Cancer Research, April 12-16, researchers report that therapies delivered by "trojan horse" peptides and through the use of nanotechnology may enhance the effectiveness of cancer treatment.
To Produce Magnetic Nanoparticles Researchers Mimic Bacteria
When it comes to designing something, it's hard to find a better source of inspiration than Mother Nature. Using that principle, a diverse, interdisciplinary group of researchers at the U.S. Department of Energy's Ames Laboratory is mimicking bacteria to synthesize magnetic nanoparticles that could be used for drug targeting and delivery, in magnetic inks and high-density memory devices, or as magnetic seals in motors.
How Tumors Manipulate The Human Vascular System Studied In Mouse Model
The formation of new blood vessels, or angiogenesis, is an Achilles' heel of tumor growth, because tumors depend on the supply of oxygen and nutrients for survival. Therefore, for some years now substances called angiogenesis inhibitors have been used in cancer treatment to suppress this process.
In Animal Model Molecule Prompts Blood Stem Cells To Help Repair Heart Damage
Researchers at UT Southwestern Medical Center have for the first time used drug-treated blood stem cells to repair heart damage in an animal model, results that might point to methods for healing injuries from heart attacks or disease.In the study, researchers screened about 147, 000 molecules to find one that could transform human blood stem cells into a form resembling immature heart cells.
Stopping Unwanted Cell Death: Implications For Drug Discovery
Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. Induced by trauma such as a heart attack or stroke, this form of necrotic death can result in tissue damage contributing to death or long-term disability.
A Better Mouse Model For Cancer Research
Researchers at Boston College have developed the first laboratory mouse model that mimics cancer's spread through the human body. Using their novel cell line, the team discovered one of the body's primary defensive cells plays a role in cancer's attack.
Atherosclerosis-Associated Biochemical Signals May Damage Other Organs
Many scientists view atherosclerosis, or hardening of the arteries, as a localized disease characterized by the build up of fatty plaques in the arteries, which can eventually cause heart attacks and strokes. Now, in a finding that challenges conventional knowledge, researchers in New York and North Carolina report that plaques formed in arteries are associated with certain harmful chemical reactions that can contribute to damage in the lungs, liver, and other organs.
Researchers Discover 'Modus Operandi' Of Heart Muscle Protein
Researchers at the University of Pennsylvania School of Medicine have discovered that a protein called leiomodin (Lmod) promotes the assembly of an important heart muscle protein called actin. What's more, Lmod directs the assembly of actin to form the pumping unit of the heart.
News From The American Chemical Society, April 9, 2008
Special National Meeting EditionApril 9, 2008This issue is a special edition with selections from scientific presentations scheduled for the ACS' 235th national meeting in New Orleans. Our regular coverage of reports from ACS' 36 major peer-reviewed journals and Chemical & Engineering News will resume with the April 16, 2008, edition.