Medarex Announces Initiation Of Phase 2 Clinical Trials For The Treatment Of Ulcerative Colitis And Rheumatoid Arthritis
Medarex, Inc. (Nasdaq: MEDX) announced that it has initiated the Phase 2 clinical development program of MDX-1100, a fully human monoclonal antibody that targets CXCL10 (also known as IP-10), in ulcerative colitis (UC) and rheumatoid arthritis (RA).
Study Of Anti-CD20 Therapy Effective B Cell Depletion
B cells, precursors of autoantibody-secreting cells, have emerged as promising new therapeutic targets in autoimmune diseases, including rheumatoid arthritis (RA). In particular, B cell depletion with the anti-CD20 antibody rituximab seems to work for RA patients resistant to standard disease-modifying antirheumatic drugs (DMARDs) and tumor necrosis factor a (TNFa) blockers.
Rheumatoid Arthritis: Fully-automated Anti-CCP Assay Launched By Roche Diagnostics
Roche Diagnostics announced the launch of a fully-automated immunoassay for the determination of autoantibodies to cyclic citrullinated peptides (Anti-CCP). The assay has been CE approved for use on the Elecsys / cobas e electrochemiluminescence immunoassay systems.
Medication For Juvenile Rheumatoid Arthritis Confirmed Effective By Study
Juvenile rheumatoid arthritis (JRA) is a chronic autoimmune disease that strikes children between the ages of newborn to 16 years. All children with JRA have joint pain, stiffness, and swelling and some also have fever and skin rashes. JRA can impede growth, damage joints, and lead to disability in adulthood.
Increased Risks For Infection And Dislocation Faced By Obese Patients Following Revision Hip Replacement Surgery
Along with age and injuries, obesity is a leading risk factor for osteoarthritis (OA), a painful and disabling joint disease. While excessive weight can aggravate the toll on almost any joint, obesity has been associated with a higher prevalence of hip OA and an increase in total hip arthroplasty (THA).
Risk Of Knee Osteoarthritis Progression May Be Reduced By Use Of A Cane
A common, incurable joint disease, osteoarthritis (OA) is the leading cause of disability in elderly people. While nearly any joint can be affected, OA most often strikes the knee, particularly the inner aspect of the tibiofemoral joint. One source of stress on this vulnerable joint compartment is the knee adduction moment, an indication of weight placement while walking.
Actemra Inhibits Joint Damage And Improves Physical Function Of Patients With Rheumatoid Arthritis
Roche announced that Actemra (tocilizumab) can significantly inhibit structural damage to joints in patients with rheumatoid arthritis (RA), a critical measure of effectiveness of an RA treatment. Actemra also improved the patients' physical function after one year of therapy, leading to a better quality of life.
Molecular Response Of Cartilage To Injury Identified By Study
It's an unfortunate fact backed by studies of former professional football and soccer players: injury to joint cartilage escalates the risk of developing of osteoarthritis (OA). However, why this occurs - the details of how joint cartilage cells respond to acute trauma and how this response leads to progressive cartilage degradation - remains open to investigation.
Attorney General Martha Coakley Files Judgment Against Merck Pharmaceutical For The Company's Deceptive Marketing Of Vioxx
Attorney General Coakley's Office filed a settlement with New Jersey-based drug manufacturer Merck and Company, Inc.(Merck) resolving concerns about the company's deceptive advertising and promotion of the "Cox-2" inhibitor drug Vioxx which is a non-steroidal anti-inflammatory drug used to treat arthritis.
Arthritis Unnecessarily Stops Many US Diabetics Taking Needed Exercise
About half of US adults with diabetes also have arthritis, which appears to be a barrier, in addition to lack of time and being too busy with other things, because they are not sure what exercise is appropriate and they are concerned about aggravating joint pain and causing further damage.