Historically A Disappointment, Neuroprotective Drug Strategies Pursuing New Targets And Mechanisms
In terms of the number of people affected, neurological diseases that contributed to decline in neuronal function are sometimes considered the newest healthcare epidemic. With the number of cases of neurodegenerative conditions expected to grow dramatically, driven by the aging population in developed countries, this therapeutic area represents one of the most compelling in both commercial and human terms.
Anti-Inflammatories Should Not Be Used To Prevent Alzheimer's, Study
Results of a US study of elderly men and women with a family history of Alzheimer's suggest that the nonsteroidal anti-inflammatory drugs (NSAIDs) naproxen and celecoxib did not improve cognitive function and the investigators recommended against using them to prevent Alzheimer's.
Tarenflurbil Trial Encouraging For Mild Alzheimer's Disease Patients
An article published in The Lancet Neurologyrecommends a phase III study for the drug tarenflurbil, amedication given to patients with mild Alzheimer's disease (AD). Thephase II study found that patients who took 800 mg of tarenflurbiltwice daily had better functional ability results than patients takingplacebo.
Presentations From 'Intracellular Traffic And Neurodegenerative Disorders' Meeting
The 23rd Colloque Medecine et Recherche of La Fondation Ipsen dedicated to the Alzheimer series was held in Paris on 28 April 2008. Entitled "Intracellular Traffic and Neurodegenerative Disorders" this meeting gathered fourteen leading researchers focused on the intracellular world.
Alzheimer Scotland Welcomes Sutherland Report On Free Personal Care
Alzheimer Scotland welcomes this landmark review which endorses the policy of free personal care for older people. Jim Jackson, Chief Executive, Alzheimer Scotland, said: "There is no cure for dementia, but the provision of personal care is as necessary for the health and well being of people with this devastating illness as medical treatment is for cancer patients.
MPs Highlight Abuse Of Human Rights Of People With Dementia, UK
An influential group of MPs is calling on the Government to stop the dangerous over-prescribing of antipsychotic drugs to people with dementia. Up to 105, 000 people with dementia are given the drugs inappropriately, according to expert predictions in the new All-Party Parliamentary Group (APPG) on Dementia report, 'Always A Last Resort', published recently.
Investigators Unveil New Drug Discovery Tool For Alzheimer's Disease
An article published in the April issue of the Journal of Alzheimer's Disease presents a detailed characterization of a new drug discovery tool for Alzheimer's disease. It demonstrates that an abnormal form of tau protein, as it occurs in Alzheimer's disease, can be produced in very simple cell models in an unambiguous way.
Journal Of Alzheimer's Disease Annual Award For Outstanding Contribution To Be Awarded To Milan Fiala, MD
Milan Fiala, MD, UCLA Orthopedic Hospital, has been chosen as the recipient of the 2008 Alzheimer Award presented by the Journal of Alzheimer's Disease in recognition of his outstanding work, "Phagocytosis of amyloid-beta and inflammation: Two faces of innate immunity in Alzheimer's disease" by M.
Anesthesia, Alzheimer's And Low Oxygen
In studies of human brain cells, the widely-used anesthetic desflurane does not contribute to increased production of amyloid-beta protein; however, when combined with low oxygen conditions, it can produce more of this Alzheimer's associated protein.
Molecules In Plants May Have Beneficial Effect On Alzheimer's Disease
A set of molecules found in certain plants appears to have a beneficial effect in brain tissue associated with Alzheimer's disease, according to a new study conducted in mice. The study was led by researchers at the University of South Florida and Cedars-Sinai Medical Center.