Researchers appear to have a new way to fix a broken heart. They have devised a method to coax heart muscle cells into reentering the cell cycle, allowing the differentiated adult cells to divide and regenerate healthy heart tissue after a heart attack, according to studies in mice and rats reported in the July 24th issue of the journal Cell, a Cell Press publication. The key ingredient is a growth factor known as neuregulin1 (NRG1 for short), and the researchers suggest that the factor might one day be used to treat failing human hearts. "To my knowledge, this is the first regenerative therapy that may be applicable in a systemic way, " said Bernhard KÃ hn of Children's Hospital Boston and Harvard Medical School.
US scientists have found a way to regenerate damaged heart tissue without using stem cells: using a growth factor called neuregulin1 (NRG1 for short), they coaxed heart muscle cells to re-enter the cell cycle, thus encouraging already differentiated adult cells to divide and make new and healthy heart tissue in the hearts of mice and rats who had suffered heart attacks. They hope this method can one day be used as an alternative or a complement to stem cell therapy as a way to treat failing hearts in humans. The study was the work of Dr Bernhard KÃ hn and colleagues and appears in the 23 July issue of Cell. KÃ hn and colleagues are from the Department of Cardiology at the Children's Hospital, and the Department of Pediatrics at Harvard Medical School, both in Boston, Massachusetts.
The risk of developing deep vein thrombosis during a long flight is often overestimated. According to the German Institute for Quality and Efficiency in Health Care (IQWiG), this condition is very unlikely in healthy travellers. When people wear a cast or splint after a sports accident, on the other hand, many are not aware that they have an increased risk of deep vein thrombosis in their leg and pelvic area. This is emphasised in information published on IQWiG's website Informed Health Online. Blood clots can travel to lungs, leading to pulmonary embolism If you are unable to move your legs regularly, blood flow through your veins is slower than usual.
Repeated encouragement and verbal instruction do not motivate stroke survivors to be physically active, and other more intensive strategies need to be found, concludes a study published on bmj.com. It is well known that even moderate physical activity can reduce the risk of cardiovascular disease and first stroke and physical exercise is also recommended for stroke survivors. Counselling on physical activity can motivate some elderly sedentary people to improve their level of physical activity, and previous studies have shown that physical activity can improve balance, walking ability and fitness in stroke patients. But little is known about which interventions to promote physical activity in stroke survivors are effective.
Today the National Business Coalition on Health (NBCH) released a national report on efforts of health plan programs to improve cardiovascular disease (CVD) care and prevention. NBCH used data from eValue8(TM), the nation's leading standardized Request for Information (RFI), a tool utilized by employers and coalitions to measure and compare health plan performance. It is estimated that 80 million Americans have some form of heart disease including high blood pressure, coronary heart disease, stroke or heart failure. Risk factors for heart disease begin in the working age population and almost 40 percent of the working age population between the ages of 40 to 69 has some type of cardiovascular disease with risk factors including high blood pressure, high cholesterol and diabetes.
Cardica Announces Publication Of Pivotal PAS-Port R Proximal Anastomosis System Clinical Trial Results
Cardica, Inc. (Nasdaq: CRDC) announced that the full results of the PAS-Port system multi-center pivotal trial, known as the EPIC trial, were published in the July issue of the peer-reviewed publication The Journal of Thoracic and Cardiovascular Surgery. The PAS-Port system, which received 510(k) clearance from the U.S. Food and Drug Administration (FDA) in September 2008, creates a secure connection, or anastomosis, between a vein graft and the aorta, the main artery in the human body, during coronary artery bypass grafting (CABG) procedures. "The data published this month confirm that the PAS-Port system produces comparable patency, saves approximately five minutes per connection and eliminates the need to clamp the aorta required for hand-sewn connections, " commented John D.