Researchers have identified a mechanism that may keep a well known signaling molecule from eroding bone and inflaming joints, according to an early study published online in the Journal of Clinical Investigation. Bone is continually recycled to maintain its strength through the competing action of osteoclasts, cells that break down aging bone, and osteoblasts, which build new bone. Osteoclasts also play a central role in common diseases that erode bone, where two signaling molecules, TNF╬ and RANKL, cause too much bone breakdown. Both are known to turn on the nuclear factor kappa B complex (NF-╬ B), which turns on genes that cause the stem cell precursors of osteoclasts to mature and start eating bone.
Researchers from Boston University School of Medicine (BUSM) are recommending that menopausal women on hormone therapy (HT) continue their treatment prior to having their annual mammogram screenings. These recommendations appear as an editorial in the current on-line issue of Journal of the North American Menopause Society. Annual mammography screening is credited with a significant reduction in breast cancer mortality in women older than 50, and is considered a pillar of routine healthcare maintenance in most populations. Sensitivity, specificity, and optimal performance of mammography depend on a number of variables including breast density.
Pre- and post-menopausal women who self-rated themselves as being sexually satisfied had a higher overall psychological well-being score and scores for "positive well-being" and "vitality, " compared with sexually dissatisfied women in a study of 295 women sexually active more than twice a month. The study, published in The Journal of Sexual Medicine, also uncovered a positive association between age and well-being, but a negative association for general health. The most commonly reported sexual problems in the area of consensual sexuality in women relate to sexual desire and interest, pleasure and satisfaction, and for most women these are part of the overall sexual experience, and are inextricably related.
A compound in coffee has been found to be estrogenic in studies by Texas AgriLife Research scientists. Though the studies have not been conducted to determine recommended consumption amounts, scientists say the compound, called trigonelline or "trig, " may be a factor in estrogen-dependent breast cancer but beneficial against colon cancer development. "The important thing to get from this is that 'trig' has the ability to act like a hormone, " said Dr. Clinton Allred, AgriLife Research nutrition scientist. "So there is a tie to cancer in the sense that we are looking at estrogen-dependent cancer cells. But that doesn't suggest that it would actually cause the disease.
Post-menopausal women who engage in moderate to vigorous exercise have a reduced risk of breast cancer. This comes from researchers writing the open access journal BMC Cancer who investigated the link between breast cancer and exercise. "With an estimated 182, 460 new cases diagnosed in the United States in 2008, breast cancer is recognized as the most common cancer affecting U.S. women" says Dr. Tricia M Peters from the U.S. National Cancer Institute, Bethesda, Maryland, who headed up an international team of researchers. Vigorous exercise has been hypothesized to reduce cancer risk for some time. However, this new study is one of the first prospective investigations to look at the importance of various intensities of exercise at different stages in an individual's life.
Michael Holick, PhD, MD, director of the Bone Healthcare Clinic and the Vitamin D, Skin and Bone Research Laboratory at Boston University School of Medicine BUSM recently received the 2009 NAMS/Upsher-Smith Laboratories, Inc.Vitamin D Research Award from the North American Menopause Society (NAMS). Holick was presented with the award during NAMS' 20th annual meeting in San Diego, California on September 30 - October 3, 2009. NAMS/Upsher-Smith Laboratories, Inc. Vitamin D Research Award recognizes an individual whose body of research has advanced the understanding of the role of vitamin D-either endogenous or exogenous-for peri-and postmenopausal women.