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Early Menopause Can Result In Earlier Onset Dementia

Women experiencing an early onset of menopause could develop dementia at a younger age. Research by Tonnie Coppus of Erasmus MC has indicated this. She studied women with Down Syndrome, who are known to have an early onset of menopause. The results of her research can be translated to apply to the general population. Her results are published in the Journal of Alzheimer Disease. Women with Down Syndrome have an earlier onset of menopause compared to women in the general population, 44 years of age and 52 years of age, respectively. Coppus' findings show a strong relationship between the age of menopause onset and the age at which dementia is diagnosed.

Depomed Announces Allowance Of U.S. Patent Covering Gastric Retentive Gabapentin Dosage Forms

Depomed, Inc. (NASDAQ:DEPO) announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for a U.S. patent application (No. 12/239, 591) directed to pharmaceutical dosage forms that deliver the compound gabapentin via Depomed's proprietary Acuform® gastric retentive drug delivery technology. Paul B. Simboli, Depomed's senior director of Intellectual Property, noted that with the issuance of this additional patent, Depomed will hold six U.S. patents covering DM-1796, its product candidate for postherpetic neuralgia licensed to Solvay Pharmaceuticals, and holds or has sublicensed seven U.S. patents covering SeradaTM, its product candidate for menopausal hot flashes.

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Depomed Comments On FDA Guidance And Plans For One Additional Phase 3 Clinical Trial Evaluating Non-Hormonal Therapy For Menopausal Hot Flashes

Depomed, Inc. (NASDAQ:DEPO) announced it has received guidance from the FDA in formal meeting minutes from a meeting held in December regarding SeradaTM, the company's extended release gabapentin product candidate for the treatment of menopausal hot flashes. Based on guidance reflected in the meeting minutes, Depomed plans to conduct a single additional pivotal Phase 3 trial evaluating Serada for the treatment of menopausal hot flashes. The company expects to initiate the trial, which will be known as Breeze 3, by the end of April 2010 and to complete the trial by the end of the first quarter of 2011. The FDA has agreed to review the proposed Breeze 3 study protocol under the FDA's Special Protocol Assessment (SPA) process.

Aneeve To Develop Sensors To Monitor Hormone Levels For Menopause, Fertility

Aneeve Nanotechnologies LLC has been selected to work in the UCLA on-campus Technology Incubator Program at the California NanoSystems Institute. The startup company will conduct early-stage research for the development of a novel hormone sensor/meter for biomedical applications in the areas of infertility and menopause. Aneeve has licensed related carbon nanotube technology from UCLA developed by Kang Wang, a UCLA professor of electrical engineering. The technology increases hormonal detection sensitivity significantly, allowing detection beyond traditional sensors. The company is using this technology to develop biomedical applications that are low in power consumption and small in size and that involve ultra-sensitive nanoelectronic technologies.

Appeals Court Reinstates More Than 100 Lawsuits Against Makers Of HRT Prempro

The 8th U.S. Circuit Court of Appeals in St. Louis on Wednesday reinstated more than 100 lawsuits against pharmaceutical companies filed by women or their surviving relatives claiming that the companies' hormone replacement therapy drugs caused breast cancer, the AP/San Francisco Chronicle reports. The AP/Chronicle reports that the women -- whose ages ranged from their 30s to their 80s -- received the HRT drugs, such as the combination estrogen-progestin drug Prempro, to treat symptoms of menopause. There are several thousand similar lawsuits filed nationwide. The appellate court's decision overturns a 2008 district court's dismissal of the cases that prevented them from being heard in state courts in Arkansas and Minnesota.

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HIV-Infected Postmenopausal Women At High Risk For Bone Fractures

According to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM), postmenopausal HIV-infected women have a high prevalence of low bone mineral density and high bone turnover placing them at high risk for future bone fractures. "As HIV-infected individuals live longer with potent antiretroviral therapy (ART), metabolic complications such as low bone density and osteoporosis are increasingly recognized, " said Michael Yin, MD of Columbia University Medical Center in New York and lead author of the study. "Although numbers of HIV-infected postmenopausal women are increasing and postmenopausal women are at highest risk for osteoporotic fractures, few studies have evaluated skeletal status in this group.

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