Carbapenems And Other Agents That Provide Broad-Spectrum Activity Are Preferred By Surveyed Physicians For The Treatment Of Intra-Abdominal Infections
Arlington Medical Resources (AMR) and Decision Resources find that surveyed physicians will increase prescribing of Wyeth's Tygacil, Merck's Invanz and Johnson & Johnson's Doribax in the next five years for the treatment of intra-abdominal infections because of their potent broad-spectrum activity and efficacy against gram-negative and anaerobic organisms. "Treatment for intra-abdominal infections is largely empiric, " stated Lisa Arias, analyst at Decision Resources. "A variety of organisms, particularly gram-negative aerobic bacteria and anaerobes, are documented in patients with an intra-abdominal infection. In fact, the leading attribute that physicians surveyed look for in a drug to treat intra-abdominal infections is its activity against anaerobes.
Data From Enzo Therapeutics' Phase II Study Of Crohn's Disease Presented At Prestigious Gastroenterology Conference
Enzo Biochem, Inc. (NYSE: ENZ), a biotechnology company specializing in gene identification and genetic and immune regulation technologies for diagnostic and therapeutic applications and laboratory services, announced that data from a Phase II clinical trial was presented today at Digestive Disease Week, the largest international gathering of academic researchers and practicing physicians in gastrointestinal medicine, held this year in Chicago. The data indicate that Alequel™ , the Company's investigational individualized oral immune regulation preparation, may be effective for the treatment of moderate-to-severe Crohn's disease.
Obesity is now acknowledged as a chronic disease with a number of related complications, and its prevalence has reached alarming epidemic proportions. While bariatric surgery is effective at treating the disease, access to this procedure is still too limited in Canada. The latest article published by Dr. Nicolas Christou, of the McGill University Health Centre (MUHC), in the June issue of the Canadian Journal of Surgery assesses the waiting times for this procedure. According to the study, the average waiting time for bariatric surgery in Canada is 5 years, a timeframe that is long compared with the 8-week average for cancer surgery or the 18-month average for cosmetic surgery.
Pi-deficiency in traditional Chinese medicine (TCM) is one of the most common digestive diseases and usually the equilibrium of gastrointestinal microflora are broken, which plays many important roles in the growth, development and performance of the host. Therefore, more clinical interests are arising in monitoring changes of intestinal microflora in intestinal disease and the consequent treatment, especially in TCM therapies. It has been found that some Chinese materia medica have curative effects on regulating the equilibrium of intestinal microflora and therefore promote the recovery of 'Pi'. However, ways of monitoring the intestinal flora are quite limited, not only because of the complexity of its constitution, but also the difficulty of culturing for most gastrointestinal bacteria in vitro.
Salix's Once-Daily APRISO Demonstrates Long-Term Safety In Patients For Maintenance Of Remission From Ulcerative Colitis
Data was announced today that demonstrated Salix Pharmaceuticals' (NASDAQ:SLXP) APRISO™ (mesalamine) 0.375g extended-release capsules had a favorable safety profile in patients in remission from ulcerative colitis (UC) for up to 24 months. APRISO is approved for use up to six months. The majority of treatment-emergent adverse events were mild or moderate in intensity, and were similar to what was seen during the 6-month phase 3 trials. The study, which is the first to examine the long-term safety profile of APRISO, was presented at the Digestive Disease Week (DDW) annual meeting in Chicago, Illinois. "It is important to provide UC patients with a new treatment option that can be safely used over the long-term, " said Dr.
An electronic diagnostic tool called the SmartPill is swallowed by patients in order to take measurements as it travels through the gastrointestinal tract. A new study by physician-scientists at NewYork-Presbyterian/Weill Cornell Medical Center used the device in patients with mild to moderate ulcerative colitis (UC), determining that they have significantly more acidic pH in their colons, compared with the average person -- a finding that may impact treatment strategy. The study was presented today at the Digestive Disease Week (DDW) meeting in Chicago, Ill. "By using the SmartPill to measure the pH throughout the digestive tract, we were able to see how the pH levels can vary in patients with ulcerative colitis.