Patients with stage III or IV melanoma taking ipilimumab and the oral steroid budesonide to reduce side effects did not have less diarrhea, a known side effect of ipilimumab, according to results of a phase II trial published in Clinical Cancer Research, a journal of the American Association for Cancer Research. These findings would "discourage the prophylactic use of budesonide to reduce the gastrointestinal side effects of ipilimumab, " said researcher Jeffrey Weber, M.D., Ph.D. Weber is a senior member at the Moffitt Cancer Center and director of the Donald A. Adam Comprehensive Melanoma Research Center, Tampa, Fla. Weber and colleagues gave 10 mg/kg of ipilimumab to 115 patients every three weeks, for four doses.
US researchers found that patients who regularly took aspirin after being diagnosed with colorectal cancer had a reduced risk of dying from the disease, and the benefit was greater for patients with a type of colon cancer where the tumors overexpress the COX-2 enzyme, which happens in around two thirds of cases. However, more work needs to be done to confirm the result before applying it to patient care, said the researchers. The study was the work of investigators from Massachusetts General Hospital (MGH), Dana-Farber Cancer Institute and Brigham and Women's Hospital and is published online in the 12 August issue of the Journal of the American Medical Association (JAMA).
For her PhD thesis, the researcher studied the genetic profiles of 175 cases of patients suffering from celiac illness, in order to determine which genes are related to the disease and to study diagnostic methods. The objective of this research was to identify the genes associated with celiac disease. The author of the PhD thesis is Ms Itziar Zubillaga Azpiroz. Her thesis was entitled, Molecular genetic analysis of celiac disease and its contribution to diagnosis. It is currently known that 40% of the genetic tendency to contracting the illness is due to Class II HLA genes specifically to HLA-DQA1 and HLA-DQB1 genes. In her work, Ms Zubillaga analysed HLA Class II genes in a number of celiac patients and she showed once again that the presence of HLA-DQA1, HLA-DQB1 and HLA-DRB1 genes confers a genetic susceptibility to contracting the disorder.
Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic inflammatory liver disease characterized by diffuse fibrosing inflammation of intra- and/or extrahepatic bile ducts, resulting in bile duct obliteration, biliary cirrhosis, and eventually hepatic failure. One of the most common symptoms at the time of presentation of PSC is mild to severe abdominal pain localized in the right upper quadrant. However, the mechanisms responsible for the abdominal pain in PSC are not fully understood. A research team led by Karouk Said from Karolinska University Hospital addressed this problem. Their study was published n the World Journal of Gastroenterology.
Pancreatitis means inflammation of the pancreas that can appear in two very different ways. Acute pancreatitis is sudden while chronic pancreatitis is recurring or persistent. Some cases of pancreatitis may be mild and go away on their own and do not require treatment. However, severe cases can lead to potentially fatal complications. Acute pancreatitis is uncommon. According to the National Health Service (NHS), UK, less than 1 in every 100, 000 people develops acute pancreatitis each year. It is slightly more common in men than in women. The pancreas is a long, flat gland located behind the stomach in the upper abdomen. It produces digestive enzymes and hormones which regulate how the body processes glucose.
By washing your hands after digging in beach sand, you could greatly reduce your risk of ingesting bacteria that could make you sick. In new research, scientists have determined that, although beach sand is a potential source of bacteria and viruses, hand rinsing may effectively reduce exposure to microbes that cause gastrointestinal illnesses. "Our mothers were right! Cleaning our hands before eating really works, especially after handling sand at the beach, " said Dr. Richard Whitman, the lead author of the U.S. Geological Survey (USGS) study. "Simply rinsing hands may help reduce risk, but a good scrubbing is the best way to avoid illness.