Barrett's epithelium is recognized as a complication of erosive esophagitis and is the pre-malignant condition for adenocarcinoma of the esophagus. A research team from Yokohama City University School of Medicine hypothesized that some macroscopic features of Barrett's epithelium might be useful for identifying a subgroup with a high risk for the development of esophageal adenocarcinoma. Their study was published on January 28, 2010 in the World Journal of Gastroenterology. They enrolled 869 patients who underwent endoscopy during a health checkup at their hospital. Based on the Prague C & M Criteria, they originally classified cases of Barrett's epithelium into two types based on its shape, namely, flame-like and lotus-like Barrett's epithelium, and into two groups based on its length, its C extent < 2 cm, and â 2 cm.
Although inflammatory bowel disease (IBD) [comprising mainly Crohn's disease (CD) and ulcerative colitis (UC)] is thought to affect about 150 000 people in the United Kingdom, the prevalence of severe IBD is not known. Mortality following hospitalization for IBD is significant but little has been reported on long-term follow-up. A research article published on January 28, 2010 in the World Journal of Gastroenterology addresses this problem. The research team from United Kingdom determined the hospitalized prevalence of severe IBD and subsequent 5-year mortality in Wales, and investigated associations between severe IBD and social deprivation, distance travelled to hospital, and other socio-demographic characteristics.
The number of Americans buying prescription drugs to treat digestive conditions climbed over 50 percent, rising from 18.1 million to 29 million people between 1997 and 2007, according to the latest News and Numbers from the Agency for Healthcare Research and Quality. Total annual spending for these drugs increased from $7 billion to nearly $19 billion from from 1997 to 2007 ( in 2007 dollars). Other findings include: - The proportion of children ages 17 and younger who had at least one prescription drug for a digestive condition purchased rose from 1.5 percent to 2.5 percent. This trend held true for seniors - increasing from 18.6 percent to 26.
Patients with mild gallstone pancreatitis usually stay in the hospital for several days, waiting for the symptoms to subside, before undergoing surgery to remedy the condition. A new study from researchers at Los Angeles Biomedical Research Institute (LA BioMed) indicates patients may no longer have to wait so long for surgery and could leave the hospital sooner. The study, slated for publication in the Annals of Surgery in April, found surgeons could safely operate on patients with mild gallstone pancreatitis within 48 hours of admission, rather than waiting for the painful inflammation in the pancreas to subside before performing the surgery.
ArQule Announces Initiation Of Clinical Programs With ARQ 197 In Germ Cell Tumors And Colorectal Cancer
ArQule, Inc. (Nasdaq: ARQL) announced the initiation of a Phase 2, single agent trial with ARQ 197 in germ cell tumors (GCT), including testicular and non-central nervous system (non-CNS) tumors, and a Phase 1/2 clinical trial designed to evaluate the safety of ARQ 197 administered in combination with irinotecan and cetuximab in patients with metastatic colorectal cancer (CRC) who possess the wild-type form of the KRAS gene. ARQ 197 is an orally available, small molecule inhibitor of the c-Met receptor tyrosine kinase. The trials will be conducted by Daiichi Sankyo Pharma Development, a division of Daiichi Sankyo, Inc., the co-developer of ARQ 197 outside of certain territories in Asia.
Conventional hepatectomy is an effective way to treat hepatocellular carcinoma (HCC). However, it is invasive and stressful. Laparoscopic surgery, a kind of minimally invasive surgery, has recently gained considerable advances. The use of laparoscopy in hepatectomy, while technically demanding, reduces surgical invasiveness and stressfulness but still achieves complete resection with adequate margins. A research team, led by Professor Tan To Cheung from The University of Hong Kong reported a laparoscopic hepatectomy treating HCC and its recurrence in an aged cirrhotic patient and describes the surgical techniques therein. Their study was published on January 28, 2010 in the World Journal of Gastroenterology.