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Laparoendoscopic Single-Site Surgery: Initial Hundred Patients - This is the first report of a large number of patients who underwent laparoendoscopic single site surgery (LESS). The work was done at three sites (Cleveland, Ohio; Caracas, Venezuela; and Gujarat, India). Overall, 15% of all of the laparoscopic procedures at these institutions were performed using LESS between October 2007 and December 2008. These procedures included renal ablative (nephrectomy - simple, donor, and radical; partial nephrectomy; nephroureterectomy), renal reconstructive (pyeloplasty), and transvesical simple prostatectomy. Procedures were done using the r-Port in combination with bent/articulating as well as standard laparoscopic instruments.

Is The Incidence Of Uretero-Intestinal Anastomotic Stricture Increased In Patients Undergoing Radical Cystectomy With Previous Pelvic Radiation? - In the online edition of the British Journal of Urology, the Department of Urology at the University of Miami reported on the impact of prior pelvic radiotherapy (XRT) on the occurrence of uretero-intestinal anastomosis (UIA) stricture at subsequent urinary diversion. Pelvic XRT can potentially affect small blood vessels and induce tissue fibrosis. In patients who have not had prior pelvic XRT, the incidence of UIA stricture with urinary diversion ranges from 1% to 9%. This patient cohort was retrospectively identified at the University of Miami from 1992 to 2008. A total of 526 patients were identified, and of these, 65 had prior pelvic XRT (group 1, 12.

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World First: Rectal Tumor Removed Through Anus, Avoiding Painful Abdominal Incisions

The world's first patient to have a malignant rectal tumor removed through the anus, thus avoiding painful abdominal incisions, was a 76-year old woman who was able to leave the Barcelona hospital where she was treated 5 days later, with no complications, and is said to be making an excellent recovery. The surgeons are optimistic that the method can now be developed to treat a range of colorectal diseases, including cancer and diverticulitis, offering patients the benefit of fewer postoperative complications and a speedier recovery. According to a report from Barcelona issued at the end of November, a team of surgeons from the Hospital Clinic Barcelona, Spain, and Massachusetts General Hospital of Boston (Harvard University) in the US, used a procedure called NOTES (Natural Orifice Transluminal Endoscopy Surgery), an innovative surgical approach that allows surgical access using the body's natural orifices.

Memscap Components Launched With Given Imaging New Colon Pill

MEMSCAP (Paris:MEMS)(NYSE Euronext: MEMS), the leading provider of innovative solutions based on MEMS (micro-electro-mechanical systems) technology, today announces it has incorporated its key technology in the PillCam® COLON 2 video capsule manufactured by Given Imaging (Nasdaq: GIVN), the global leader in providing patient-friendly diagnostic solutions for the gastrointestinal community. PillCam COLON 2, which obtained the CE mark in September, 2009, has been launched in Europe at the Gastro 2009 conference, which took place in London, on November 23. It enables physicians to visualize the colon and includes the following improvements over its first-generation technology: a new imaging angle (172 field-of-view from each imager) offers a near 360 view of the colon;

Adolor Corporation Initiates Clinical Testing In Opioid Bowel Dysfunction Program

Adolor Corporation (NasdaqGM:ADLR) announced the initiation of clinical testing of ADL7445, its proprietary, oral mu opioid receptor antagonist for the treatment of Opioid Bowel Dysfunction (OBD). The Phase 1, single ascending dose trial in healthy volunteers will assess safety and tolerability of the compound and will be followed by a multiple ascending dose study in early 2010. Early next year, the Company also expects to initiate a clinical study of a second compound for OBD, ADL5945, in a parallel, early-stage clinical development program. ADL5945 was in-licensed from Eli Lilly in September 2009 and has a different chemical structure and pharmacokinetic profile than ADL7445.

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Strengthening Sphincters In Animals Via Muscle Cell Infusion

A new study shows that muscle cells grown in the lab can restore an intestine's ability to squeeze shut properly. The work, performed in dogs and rats, might ultimately help treat patients with conditions such as gastric reflux and fecal incontinence. This technique may be used to strengthen sphincters, which are the bands of muscle that separate the major sections of your intestinal tract. Weakness in these areas can cause gastrointestinal esophageal reflux disease, or GERD, which affects 25 million adults in the United States. It is also a cause of fecal incontinence, or loss of control of the bowels, which afflicts more than 5 percent of adults under 40, especially women after childbirth;

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