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Tolerx Completes Enrollment In DEFEND-1, A Phase 3 Type 1 Diabetes Study With Otelixizumab

Tolerx, Inc., announced the completion of patient enrollment in its Phase 3 clinical study DEFEND-1, which is evaluating the safety and efficacy of otelixizumab, a targeted T cell immunomodulator, in patients with new-onset autoimmune type 1 diabetes. The DEFEND-1 (Durable Response Therapy Evaluation For Early or New-Onset Type 1 Diabetes) study enrolled 240 patients, aged 12-45 years with newly diagnosed autoimmune type 1 diabetes. The DEFEND-1 study is investigating the ability of otelixizumab to preserve beta cell function, which may reduce the risk of both short- and long-term complications of the disease. Patients will be monitored during the 12-month follow-up period and c-peptide levels (a surrogate measure of beta cell function) will be measured as the primary endpoint.

You Have Control Over Type 2 Diabetes!

Type 2 diabetes is invisible, it is a chronic condition that does not go away. It's not like a broken arm that one day will heal... it is a condition that although it can be managed, even reversed, will always affect the way you live. It is important for you to know this though... you can exercise an enormous amount of control over type 2 diabetes. With good self-management, it is possible to successfully treat type 2 diabetes. You can delay the further advances of any physical damage caused by high blood sugar levels. Control of this condition virtually depends on how much you are prepared to become educated, to become knowledgeable about how to get your weight and blood sugar levels to fall.

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Diabetes - Women With Polycystic Syndrome - Role of Exercise

Some women are more prone to Type II diabetes due to a condition which often remains unnoticed. This is Polycystic Ovary Syndrome or PCOS. It affects between 6 to 10 % women of childbearing age and increases the risk of diabetes significantly. A prominent symptom of PCOS is excessive weight gain with most of it around the abdomen. Besides, erratic menstrual cycles, acne, excessive body or facial hair may also point to PCOS. These symptoms result from a hormonal imbalance caused by PCOS. If you have some or all of these symptoms, consult your doctor without delay. He can diagnose PCOS and guide you to proper treatment so as to control it and avoid possible complications like heart diseases, infertility, endometrial cancer, and of course diabetes.

Nitric Oxide-Releasing Cloth For Therapeutic Socks And Wrap For Donor Organs

Scientists in Texas are reporting development of a first-of-its-kind cloth that releases nitric oxide gas - an advance toward making therapeutic socks for people with diabetes and a wrap to help preserve organs harvested for transplantation. The study is in ACS' Chemistry of Materials, a bi-weekly journal. Kenneth Balkus and Harvey Liu note in the new study that nitric oxide (NO) helps increase blood flow and regulates a range of other body functions. Scientists have tried for years to find practical ways to store and deliver NO for use in medicine. However, they have had difficulty finding a suitable material that allows controlled delivery of NO.

Diabetes - Some Facts You Should Know

When you are diagnosed with high blood sugar level, that is diabetes, your first reaction is that of shock; and then all sorts of negative thoughts descend upon you - now I will have to stay indoors and keep injecting myself with insulin, now it's the end of the world for me. Is it? Well, perhaps it is time for you to know certain facts about diabetes so that you accept it as a part of your life and take it in your stride. What is Diabetes? The food we take is ultimately broken down by our body into glucose, a form of sugar. With the help of a particular hormone known as insulin, our body converts this glucose into energy which is required for us to live and work.

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More Evidence On Benefits Of High Blood Pressure Drugs In Diabetic Eye Disease

Scientists in Massachusetts are reporting new evidence that certain high blood pressure drugs may be useful in preventing and treating diabetic retinopathy, the leading cause of vision loss in people with diabetes. The study, the largest to date on proteins in the retina, could lead to new ways to prevent or treat the sight-threatening disease, they say. The findings are in ACS' Journal of Proteome Research, a monthly publication. Edward Feener and colleagues point out that diabetic retinopathy is a common complication of diabetes, which affects millions of people worldwide. It involves damage to blood vessels in the retina, the light sensitive tissue in the back of the eye.

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