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NIH Funds Donkeywork At WPI On Regenerating Heart Tissue And Preventing Urinary Tract Infections

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Congressman James McGovern, D-Massachusetts, has announced National Institutes of Health (NIH) awards for two researchers at Worcester Polytechnic Institute's Life Sciences and Bioengineering Centre at Gateway Park.
Glenn Gaudette, PhD, assistant professor of biomedical engineering at WPI, testament receive $403,000 over two age to advance his work using bone marrow derived stem cells to restore assistance to damaged hearts. Terri Camesano, PhD, associate professor of chemical engineering at WPI, will accept $218,000 over two years to linger her studies of how cranberry sap prevents urinary tract infections. The grants are the ahead NIH awards for both Gaudette and Camesano, marking an critical milestone for the investigators.
"I am satisfied to see the NIH continues to recognize the cardinal trial vitality done at WPI," said Congressman McGovern. "The NIH is the gold-standard for biomedical test in the United States, and these awards further extend Worcester's position as a important center for the heart sciences."
Commenting on the new awards and the growing concentration of NIH funded research at the university, W. Grant McGimpsey, WPI's associate provost for analysis and graduate studies ad interim, said "receiving NIH funding, after a rigorous file from their peers, is a above achievement for our young investigators. It validates the scholarship and creativity of their work. More important, though, is the progress these and other exciting proof programs at WPI are production to help translate basic science discoveries into doable therapies and technologies that will corrective people."
In previous studies, Camesano has shown that cranberry liquor hinders the competence of the bacteria E.coli to adhere to the epithelial cells that limit the interior of the urinary tract. Bacterial adhesion is the first manner toward infection. In the new study, Camesano's team will analyse how cranberry juice affects the molecular mechanisms involved in that initial latching-on process, using atomic conscription microscopy to degree the forces involved. The site is to establish the optimal cranberry serum potion and exposure time to prevent bacterial adhesion. As item of the au courant study, Camesano will collaborate with Joseph Grocela, MD, a urologist and clinical researcher at the Massachusetts Common Hospital, who will provide samples of epithelial cells taken from women who suffer from chronic urinary tract infections (UTIs). Camesano's lab will observe how the cells cope when they are challenged by E.coli and treated with cranberry juice. The intention is to prosper a new therapy for UTIs that does not rely on antibiotics.
Gaudette's lab explores the lurking for human mesenchymal stem cells (hMSCs), which come from the bone marrow, to regenerate cardiac tissue, thereby helping a damaged heart beat more effectively. Love attacks argument significant scaring of cardiac tissue, which in turn prevents the scarred world of the feelings from contracting to pump blood. New studies by Gaudette and others corner shown that when hMSCs are injected into a damaged heart, they support better cardiac function. Working with WPI colleagues George Pins, PhD, associate professor of biomedical engineering, and Marsha Rolle, PhD, assistant professor of biomedical engineering, Gaudette developed a course for seeding biopolymer microthreads with hMSCs, then stitching those threads directly into a damaged heart. The method significantly improves the intelligence to corner the hMSCs at precise points in the heart to improve overhaul in the damaged area. The fresh read aims to develop processes for maximizing the number of hMSCs that can be loaded onto the threads, and then to study the denouement of the cells on cardiac function in a rat model.
Michael Cohen
Worcester Polytechnic Faculty
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