Chronicle Of American School Of Cardiology Article Reports Fewer Repeat Procedures With Boston Scientific's TAXUS R Liberte R Stent
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Boston Scientific Partnership (NYSE: BSX) welcomed the publication of an article in the current edition of the Log of American College of Cardiology (JACC) reviewing data on more than 19,000 patients from the Swedish national registry who were evaluated for restenosis, or the re-narrowing of arteries after percutaneous coronary intervention (PCI). The article reported that patients who received a TAXUS(R) Liberte(R) Paclitaxel-Eluting Stent had numerically lower incidences of repeat procedures to treat restenosis at two senility as compared to patients treated with 'olimus-based drug-eluting stents (DES), including Cordis' Cypher(R) Stent and Medtronic's Endeavor(R) Stent. In the patients with diabetes, the TAXUS Liberte Stent demonstrated a statistically significant lower restenosis standard compared to the Endeavour Stent, which had extra than two times the risk of repeat procedures.
The Swedish Coronary Angiography and Angioplasty Registry holds data on all patients undergoing PCI in Sweden. The purpose of this independent discover was to evaluate restenosis rates of drug-eluting stents in patients with and without diabetes in a real-world setting. The JACC article reported that both the TAXUS Liberte Stent and Boston Scientific's first-generation DES -- the TAXUS(R) Express(R) Stent -- were the only stents in the study showing no increased risk of restenosis for patients with diabetes as compared to those without diabetes. Both the Cypher Stent and Endeavor Stent showed significant increased risk of restenosis in patients with diabetes. In addition, the scan showed that the TAXUS Liberte Stent had an approximately 23 percent lower restenosis rate at two elderliness compared to the prior-generation TAXUS Express Stent. The authors concluded that "There seem to be relevant differences between at odds brands of DES."(1)
"The results of this study are noteworthy for TAXUS Liberte, which compared favourably in rates of repeat procedures to both 'olimus stents," said Donald S. Baim, M.D., Chief Medical and Scientific Officer of Boston Scientific. "The findings presented in the article are consistent with our own clinical trial observations, including recently published ARRIVE and ATLAS data, and may give forth the different mechanism of enterprise for paclitaxel compared to the 'olimus agents used in the other drug-eluting stents. The newer and thinner-strut TAXUS Liberte Stent performed better than the TAXUS Clear-cut Stent in reducing restenosis."
The Swedish registry peruse included four DES brands: TAXUS Liberte, TAXUS Express, Cypher and Endeavor. In total, the registry included 35,478 DES implants during 22,962 procedures in 19,004 patients, with 1,807 restenoses reported over a penny-pinching 29-month follow-up period. For the comprehensive study population, the repeat revascularization scale per stent was 3.5 percent after one year and 4.9 percent after two years. Overall, the adjusted risk of restenosis was 1.23 times higher in patients with diabetes than in patients without diabetes. In patients with diabetes, restenosis was higher in the non-TAXUS Stents. The sirolimus-eluting Cypher Stent and the zotorolimus-eluting Endeavor Stent had higher restenosis rates in patients with diabetes compared with those in patients without diabetes (1.25 times and 1.77 times, respectively).
"The Swedish recite shows there are eloquent distinctions among available DES, as well as differences between first- and second-generation products," said Twist Kucheman, Senior Vice Head of the state and Collection President, Cardiovascular for Boston Scientific. "Our two-drug strategy has allowed us to maintain our global DES direction position by offering the next-generation TAXUS Liberte Stent as hardy as the PROMUS(R) Everolimus-Eluting Coronary Stent. We glimpse forward to introducing our third-generation Element(TM) Stent on both narcotic platforms successive this year in CE Speck countries."
TAXUS Stents annex been evaluated by the industry's most spread out randomized, controlled clinical trial program, with follow-up to five years in some cases. These check results have been supplemented by material on besides than 35,000 patients enrolled in post-approval registries. To date, sorrounding 11 million Boston Scientific stents admit been implanted globally, forming them the world's most often used stents.
The TAXUS Liberte Paclitaxel-Eluting Coronary Stent Manner received U.S. Eatable and Drug Governance approval in October 2008, and received European CE Mark approval for utilize in patients with diabetes in December 2007. In the United States, the TAXUS Stents are not specifically indicated for convenience in patients with diabetes.
The PROMUS Stent is a private-labeled XIENCE V(R) Everolimus-Eluting Coronary Stent Method manufactured by Abbott and distributed by Boston Scientific. XIENCE V is a trademark of the Abbott Laboratories group of companies. Cypher is a trademark of Cordis Corporation. Endeavor is a trademark of Medtronic Vascular, Inc.
Boston Scientific is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a wide range of interventional medical specialties.
(1) (J Am Coll Cardiol 2009;53:1660-7)
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