TAU Research Produces New Non-Invasive Procedure To Predict And Treat Love Attacks
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Twenty percent of American deaths each year are caused by passion drive or angina, sometimes without any warning.
But thanks to new research from Dr. Sharon Zlochiver of the Department of Biomedical Engineering at Tel Aviv University, there's latest hope for potential heart assailing victims. By looking at the electrical activity coupling two types of heart muscle cells, Dr. Zlochiver has discovered a virgin hang-up of identifying an impending attack.
Dr. Zlochiver can not only predict when a emotions aggression testament occur, but he can also advice doctors - and patients - obtain time before a deadly encounter takes place. His proof was published endure year in the Biophysical Journal.
Keeping His Eye on the Balance
"Seventy percent of the heart is false up of myocytes, which are contractile muscle cells. The remaining 30% is mostly laborious structural cells called fibroblasts that profession to hold the muscle in place," Dr. Zlochiver explains. "As the heart ages and contends with factors such as flying blood power or genetic disease, this balance begins to change."
Through the succession of his research, which was started at the University of Michigan, Dr. Zlochiver developed a mathematic imitation that shows when the proportion of structural fibroblast cells are at dangerous levels, at on all sides of 70% of the heart's volume. According to Dr. Zlochiver, this is the "tipping point" where a affection dirty deed is imminent.
The disagreement has been that these cells are not apparently differentiated from one another, which presented a remonstrance to Dr. Zlochiver. Though a accepted EKG could not commit the news he sought, Dr. Zlochiver was decided to flash how the cell ratio within the feelings could be measured by electrical activity. Studying the electric coupling - tiny electric signals - between myocytes and fibroblast cells, he was able to distemper a more accurate picture of a heart's health than could be deduced from still an MRI or CT scan.
"This coupling is crucial to the initiation of fibrillation," he says. Indicating how the electrical impulses movement in a healthy heart, in a synchronized ordered manner, he compares that to a diseased heart, where electric coupling is scattered and irregular and the impulses break into chaotic resident "tornados."
"Abnormal electrical activity causes the heart to contract abnormally," he says. Working with his colleagues at the University of Michigan, Dr. Zlochiver is working to repair hearts in real patients at risk prophylactically, so that electrical coupling signals in diseased hearts resemble a extra organized, "tornado-free" pattern.
Fixing a Broken Heart by Email
Dr. Zlochiver's test will no suspect alter the action cardiac arrest is diagnosed and treated. "If we get an image from an MRI or CT from the inside of the heart, we can cause a mathematical model and simulate electrical activity. That way, we can identify the problem mark and cessation fibrillation," he says.
"We can end the consciousness of the electrical duration and the interplay between cells in order to dish out ideas on treatment. Physicians will own a better notion on how to treat particular patients. For example, physicians will be able to locally ablate or release drugs in cardiac areas that are chiefly susceptible to fibrillation."
In the future, Dr. Zlochiver hopes that doctors will be able to mail in scans of their patients' hearts and the models he creates from the scans would aid guide decisions on treatment.
Dr. Zlochiver, a recipient of a 2007 award from the American Heart Partnership for his work, is one of 23 blazing new college recruits to Tel Aviv University.
American Friends of Tel Aviv University
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